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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 07, 2005 |
| Title |
Intrathymic T-cell selection |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Comparisons between untreated primary cells T-cell precursors from the thymus. CD69- thymocytes are from Zap70-deficent mice and are >95% CD4+CD8+. These cells fail to generate intrathymic TCR signals as a result of their lacking Zap70 molecules, and are thus representative of "preselection" CD4+CD8+ thymocytes. The CD69hi population comes from wildtype mice and is heterogeneous for CD4 and CD8 expression. These cells have been intrathymically TCR-signaled and are undergoing selection.
Keywords: other
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| Contributor(s) |
Sun G, Liu X, Bosselut R |
| Citation(s) |
15750595 |
| Submission date |
Feb 09, 2005 |
| Last update date |
Jan 17, 2013 |
| Contact name |
Remy Bosselut |
| E-mail(s) |
remy@helix.nih.gov
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| Phone |
1-301-402-4849
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| Organization name |
NCI, NIH
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| Street address |
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
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| Samples (3) |
| GSM41736 |
CD69hi vs. CD69lo thymocytes rep 1 |
| GSM41737 |
CD69hi vs. CD69lo thymocytes rep 2 |
| GSM41738 |
CD69lo vs. CD69hi thymocytes |
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| Relations |
| BioProject |
PRJNA91373 |
| Supplementary data files not provided |
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