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| Status |
Public on May 03, 2023 |
| Title |
Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments [in vivo] |
| Organism |
Cavia porcellus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In this study we tested the ability to predict organ injury from in vivo transcriptomics data in male Hartley guinea pigs at early time points after exposure to mercury chloride (9 and 33 hours). We selected mercury chloride, a compound extensively used in animal studies for its ability to cause acute kidney damage.
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| Overall design |
We treated male Hartley guinea pigs with saline solution (control), 1.00 mg/kg (low dose), and 1.50 mg/kg (high dose) to produce different degrees of injury. RNA samples for gene expression analysis were collected from the kidney at 9 and 33 hours. Number of repicates were five.
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| Contributor(s) |
Goel H, Pannala V, AbdulHameed MD, Printz RL, Shiota C, Estes SK, Shiota M, Wallqvist A |
| Citation(s) |
37108594 |
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| Submission date |
Feb 28, 2023 |
| Last update date |
May 04, 2023 |
| Contact name |
Himanshu Goel |
| E-mail(s) |
hgoel@bhsai.org
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| Organization name |
Biotechnology HPC Software Applications Institute (BHSAI)
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| Street address |
2405 Whittier Drive, Suite 200
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| City |
Frederick |
| State/province |
MD |
| ZIP/Postal code |
21702 |
| Country |
USA |
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| Platforms (1) |
| GPL28437 |
Illumina NovaSeq 6000 (Cavia porcellus) |
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| Samples (30)
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| This SubSeries is part of SuperSeries: |
| GSE226313 |
Assessing kidney injury induced by mercuric chloride in guinea pigs with in vivo and in vitro experiments |
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| Relations |
| BioProject |
PRJNA939686 |
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