 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Sep 06, 2023 |
| Title |
Transcriptional analysis reveals the progression of PCOS to ovarian cancer in medaka fish ancestrally exposed to BPA |
| Organism |
Oryzias latipes |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
As a heterogeneous reproductive disorder with unclear etiopathogenesis, polycystic ovary syndrome (PCOS) can be caused by genetic, diet, and environmental factors. Bisphenol A (BPA), a global environmental contaminant, can induce PCOS and NAFLD due to direct exposure; however, whether these phenotypes persist in future unexposed generations is not currently understood. We observed genes abnormally expressed in the ovary of BPA lineage, similar to human PCOS patients. IPA analyses revealed activation of the cancerous pathway, arginine-proline metabolism, insulin signaling, AMPK, and HOTAIR regulatory pathways, as well as upstream regulators esr1 and tgf β.
|
| |
|
| Overall design |
RNA seq of the ovary of three biological replicates from BPA lineage and control lineage of Medaka fish
|
| |
|
| Contributor(s) |
Bhandari R, Chakraborty S, Anand S |
| Citation(s) |
37581432 |
| |
| Submission date |
Feb 28, 2023 |
| Last update date |
Sep 06, 2023 |
| Contact name |
Ramji Bhandari |
| E-mail(s) |
bhandarir@missouri.edu
|
| Organization name |
University of Missouri
|
| Department |
Division of Biological Sciences
|
| Lab |
Lefevre 219
|
| Street address |
1200 University Ave
|
| City |
Columbia |
| State/province |
MO |
| ZIP/Postal code |
65211 |
| Country |
USA |
| |
|
| Platforms (1) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA939703 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE226322_pcos_rnaseq_normExp_diffExp_filtered-Padj.tsv.gz |
925.4 Kb |
(ftp)(http) |
TSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...