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| Status |
Public on Jun 01, 2023 |
| Title |
Gene expression signatures of mammalian longevity across species |
| Organisms |
Macaca fascicularis; Papio anubis; Ursus americanus; Peromyscus leucopus; Petaurus breviceps; Castor canadensis; Tamias sibiricus; Murina leucogaster |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Lifespan varies both within and across species, but the general principles of its control are not understood. To identify transcriptomic signatures of mammalian longevity, we sequenced multiple organs of young adult mammals corresponding to 8 different species, including Canadian beaver, long-tailed macaque, greater tube-nosed bat, baboon, white-footed mouse, sugar glider, Siberian chipmunk and American black bear. We aggregated this dataset with publicly available pan-mammalian data and performed multi-tissue gene expression analyses across 41 mammalian species. This allowed us to identifiy signatures of species longevity and assess their relationship with biomarkers of aging and lifespan-extending interventions. This dataset complements RNAseq profiles of tissues from 23 mammalian species stored at GSE43013.
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| Overall design |
RNA-seq gene expression profiling of 48 liver, kidney, brain and cerebellum samples from 8 mammalian species.
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| Contributor(s) |
Tyshkovskiy A, Ma S, Gladyshev VN |
| Citation(s) |
37269831 |
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| Submission date |
Mar 14, 2023 |
| Last update date |
Jun 07, 2023 |
| Contact name |
Alexander Tyshkovskiy |
| E-mail(s) |
alex.tyshkovskiy@gmail.com
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| Organization name |
Brigham & Women's Hospital, Harvard Medical School
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| Street address |
77 Avenue Louis Pasteur
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| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (8)
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| GPL18648 |
Illumina HiSeq 2000 (Macaca fascicularis) |
| GPL18808 |
Illumina HiSeq 2000 (Papio anubis) |
| GPL33249 |
Illumina HiSeq 2000 (Ursus americanus) |
| GPL33250 |
Illumina HiSeq 2000 (Castor canadensis) |
| GPL33251 |
Illumina HiSeq 2000 (Tamias sibiricus) |
| GPL33252 |
Illumina HiSeq 2000 (Petaurus breviceps) |
| GPL33253 |
Illumina HiSeq 2000 (Murina leucogaster) |
| GPL33254 |
Illumina HiSeq 2000 (Peromyscus leucopus) |
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| Samples (48)
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| GSM7098905 |
Brain, baboon, rep 2 |
| GSM7098906 |
Kidney, baboon, rep 2 |
| GSM7098907 |
Liver, baboon, rep 2 |
| GSM7098908 |
Brain, baboon, rep 3 |
| GSM7098909 |
Kidney, baboon, rep 3 |
| GSM7098910 |
Liver, baboon, rep 3 |
| GSM7098911 |
Brain, baboon, rep 4 |
| GSM7098912 |
Kidney, baboon, rep 4 |
| GSM7098913 |
Liver, baboon, rep 4 |
| GSM7098914 |
Brain, baboon, rep 5 |
| GSM7098915 |
Kidney, baboon, rep 5 |
| GSM7098916 |
Liver, baboon, rep 5 |
| GSM7098917 |
Brain, baboon, rep 6 |
| GSM7098918 |
Kidney, baboon, rep 6 |
| GSM7098919 |
Liver, baboon, rep 6 |
| GSM7098920 |
Kidney, bear, rep 1 |
| GSM7098921 |
Liver, bear, rep 1 |
| GSM7098922 |
Brain, beaver, rep 1 |
| GSM7098923 |
Liver, beaver, rep 1 |
| GSM7098924 |
Brain, beaver, rep 2 |
| GSM7098925 |
Liver, beaver, rep 2 |
| GSM7098926 |
Liver, chipmunk, rep 1 |
| GSM7098927 |
Liver, chipmunk, rep 2 |
| GSM7098928 |
Cerebellum, long-tailed macaque, rep 1 |
| GSM7098929 |
Kidney, long-tailed macaque, rep 1 |
| GSM7098930 |
Liver, long-tailed macaque, rep 1 |
| GSM7098931 |
Cerebellum, long-tailed macaque, rep 2 |
| GSM7098932 |
Kidney, long-tailed macaque, rep 2 |
| GSM7098933 |
Liver, long-tailed macaque, rep 2 |
| GSM7098934 |
Cerebellum, long-tailed macaque, rep 3 |
| GSM7098935 |
Kidney, long-tailed macaque, rep 3 |
| GSM7098936 |
Liver, long-tailed macaque, rep 3 |
| GSM7098937 |
Cerebellum, long-tailed macaque, rep 4 |
| GSM7098938 |
Liver, long-tailed macaque, rep 4 |
| GSM7098939 |
Cerebellum, long-tailed macaque, rep 5 |
| GSM7098940 |
Kidney, long-tailed macaque, rep 5 |
| GSM7098941 |
Liver, long-tailed macaque, rep 5 |
| GSM7098942 |
Cerebellum, long-tailed macaque, rep 6 |
| GSM7098943 |
Kidney, long-tailed macaque, rep 6 |
| GSM7098944 |
Liver, long-tailed macaque, rep 6 |
| GSM7098945 |
Liver, sugar glider, rep 1 |
| GSM7098946 |
Liver, sugar glider, rep 2 |
| GSM7098947 |
Liver, tube-nosed bat, rep 1 |
| GSM7098948 |
Brain, white-footed mouse, rep 1 |
| GSM7098949 |
Liver, white-footed mouse, rep 1 |
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| This SubSeries is part of SuperSeries: |
| GSE227360 |
Distinct longevity mechanisms across and within species and their association with aging |
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| Relations |
| BioProject |
PRJNA944704 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE227359_RNAseq_raw_counts.csv.gz |
1.1 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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