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| Status |
Public on Mar 21, 2024 |
| Title |
ALK upregulates POSTN and WNT signaling to drive neuroblastoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The goal of this study is to identify the mechanism for how ALK promotes tumorigenesis in neuroblastoma. We developed a human stem cell model of neuroblastoma and generated isogenic tumors using MYCN and MYCN/ALK. RNAseq analysis of both tumors revealed an enrichment in focal adhesion signaling and allowed us to find POSTN as a key mediator of ALK-mediated tumor growth.
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| Overall design |
The samples are human stem cell derived trunk neural crest cells that were implanted into mice and developed into tumors. We have samples of WTC11 MYCN, WTC11 MYCN/ALK and 1323 MYCN tumors. The data provided is RNA-seq analysis of each of the samples in triplicate
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| Contributor(s) |
Huang M, Farrel A, Maris JM, Weiss WA |
| Citation(s) |
38451815 |
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| Submission date |
Mar 24, 2023 |
| Last update date |
Mar 22, 2024 |
| Contact name |
Miller Huang |
| E-mail(s) |
mhuang@chla.usc.edu
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| Organization name |
Children's Hospital Los Angeles
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| Department |
Pediatrics
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| Street address |
4650 Sunset Blvd, #57
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| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90027 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA948479 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE228194_RAW.tar |
12.9 Mb |
(http)(custom) |
TAR (of RESULTS) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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