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| Status |
Public on Jun 28, 2023 |
| Title |
Transcriptomic analysis reveals distinct adaptive molecular mechanism in the hippocampal CA3 from rats susceptible or not-susceptible to hyperthermia-induced seizures |
| Organism |
Rattus norvegicus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
This study aimed to identify the genomic differences - through differential gene expression, miRNAs, and WGCNA transcriptional modules among animals with or without seizure after insult and non-insulted controls.
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| Overall design |
Use of a rat (Rattus norvegicus) model of hyperthermia-induced seizure to characterize the genomic mechanism underlying febrile seizures in epilepsy. The aim of the study is to identify the genomic differences in hippocampal ventral CA3 region - through differential gene expression, miRNAs, and WGCNA transcriptional modules among animals with (HS) or without (HNS) seizure after insult and non-insulted controls (CT). Here, samples from the animal of all groups in the P12 time-interval.
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| Contributor(s) |
Bando SY, Bertonha FB, Menezes PH, Takahara AK, Khaled NA, Santos P, Junqueira MS, Cesar RM Jr, Moreira-Filho CA |
| Citation(s) |
37355705 |
| |
| Submission date |
Apr 14, 2023 |
| Last update date |
Aug 09, 2023 |
| Contact name |
Carlos Alberto Moreira-Filho |
| E-mail(s) |
carlos.moreira@hc.fm.usp.br
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| Phone |
55-11-3061-8449
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| Organization name |
Faculdade de Medicina da Universidade de Sao Paulo
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| Department |
Departments of Pediatrics
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| Lab |
LIM36
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| Street address |
Av. Dr. Eneas Carvalho de Aguiar 647
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| City |
Sao Paulo |
| State/province |
SP |
| ZIP/Postal code |
05403-900 |
| Country |
Brazil |
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| Platforms (1) |
| GPL14746 |
Agilent-028282 Whole Rat Genome Microarray 4x44K v3 (Probe Name version) |
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| Samples (17)
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| This SubSeries is part of SuperSeries: |
| GSE229760 |
Transcriptomic analysis reveals distinct adaptive molecular mechanism in the hippocampal CA3 from rats susceptible or not-susceptible to hyperthermia-induced seizures |
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| Relations |
| BioProject |
PRJNA955783 |
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