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Series GSE229957 Query DataSets for GSE229957
Status Public on Nov 12, 2023
Title Gene expression profile at single cell level of plasma cells (PCs) from human bone marrow
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs, but are reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of different tissue-resident (Tr)PC populations revealed that they each have their own transcriptional signature indicative of functional adaptation to the host tissue environment. In contrast to expectation, all TrPCs were extremely long-lived, regardless of their organ of residence, with the longevity influenced by intrinsic factors like the immunoglobulin isotype. Analysis at single-cell resolution revealed that the bone marrow is unique in housing a compendium of PCs generated all over the body that retain aspects of the transcriptional program indicative of their tissue of origin.
Overall design Plasma cells were isolated from the bone marrow of a healthy adult human donor and analyzed using scRNAseq.
Contributor(s) Smyth GK, Tarasova I, Nie J
Citation(s) 38172260
Submission date Apr 18, 2023
Last update date Feb 11, 2024
Contact name Gordon K Smyth
Phone (+61 3) 9345 2326
Fax (+61 3) 9347 0852
Organization name Walter and Eliza Hall Institute of Medical Research
Department Bioinformatics
Lab Smyth
Street address 1G Royal Pde
City Parkville
State/province Vic
ZIP/Postal code 3052
Country Australia
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (1)
GSM7181915 Bone marrow plasma cells
BioProject PRJNA956893

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Supplementary file Size Download File type/resource
GSE229957_RAW.tar 41.5 Mb (http)(custom) TAR (of MTX, TSV)
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Raw data are available in SRA
Processed data provided as supplementary file

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