|
| Status |
Public on Aug 01, 2024 |
| Title |
Pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin |
| Organism |
Staphylococcus aureus subsp. aureus NCTC 8325 |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Interrogating Staphylococcus aureus transcriptional changes in the presence or absence of glycosaminoglycans, specifically heparin.
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| |
|
| Overall design |
USA400 bacterial suspensions were grown in the presence of unfractionated heparin (2 µg/mL ) or saline control. After 3 or 10 hours of incubation, bacterial RNA was isolated and sent for sequencing (n=3 per treatment group and time point).
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| |
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| Contributor(s) |
Kwiecinski J, LaRiviere W, Erzen C, Langouet-Astrie C, Horswill A, Schmidt E, Colbert J |
| Citation(s) |
38113313 |
| |
| Submission date |
May 01, 2023 |
| Last update date |
Aug 16, 2024 |
| Contact name |
Christophe Langouët-Astrié |
| E-mail(s) |
christophe.langouetastrie@cuanschutz.edu
|
| Organization name |
University of Colorado Denver, Anschutz
|
| Department |
Pulmonary Sciences and Critical Care
|
| Lab |
Eric Schmidt
|
| Street address |
12700 E 19th Ave
|
| City |
Aurora |
| State/province |
CO |
| ZIP/Postal code |
80045 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL33368 |
Illumina NovaSeq 6000 (Staphylococcus aureus subsp. aureus NCTC 8325) |
|
| Samples (12)
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| Relations |
| BioProject |
PRJNA964773 |
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