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| Status |
Public on Jun 09, 2023 |
| Title |
Trascriptome data in the brain from Propolis treated-Alzheimer's disease model mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We showed that Brazilian green propolis attenuated Aβ-induced memory and learning impairment. Comprehensive gene expression analysis demonstrated that Brazilian green propolis treatment suppressed inflammation and immune responses via immune cells such as microglia and astrocytes in the brain. These results indicate the potential of Brazilian green propolis as a promising ingredient for preventing AD-type dementia.
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| Overall design |
Five-week-old male Slc:ddY mice were randomly divided into five groups (n=8). The groups were pretreated with vehicle and propolis at a dose of 100, 300 and 900 mg/kg body weight for 8 days, then AD-like phenotypes were induced by intracerebroventricular (ICV) injection of Aβ25‒35. A sham operation group was set as the control. Gene expression analysis was performed using the Clariom S Mouse Array (Thermo Fisher Scientific, Waltham, MA, USA).
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| Contributor(s) |
Okumura N, Degawa T, Ito T |
| Citation(s) |
37978479 |
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| Submission date |
Jun 05, 2023 |
| Last update date |
Dec 08, 2023 |
| Contact name |
Nobuaki Okumura |
| E-mail(s) |
no1780@yamada-bee.com
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| Organization name |
Yamada Bee Company, Inc.
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| Street address |
194 Ichiba Kagamino
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| City |
Tomata |
| State/province |
Okayama |
| ZIP/Postal code |
708-0393 |
| Country |
Japan |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (48)
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| Relations |
| BioProject |
PRJNA980123 |
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