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Series GSE234128 Query DataSets for GSE234128
Status Public on Jun 07, 2023
Title Transcriptional Profile of ZIKV Infection in HTR8 cells and U251 cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To identify the various host factors involved in ZIKV infection, we compared the transcriptional profile for ZIKV-infected human first-trimester placenta trophoblast cell (HTR8) and glioblastoma astrocytoma (U251-MG). Our results demonstrated that the common IFN, inflammatory cytokine, and chemokine production were activated upon ZIKV infection of these two cell types while serval DEGs were enriched in distinct biological processes related to the characteristics of cell types. Our findings identified multiple host factors associated with ZIKV pathogenesis and potential treatment of congenital zika syndrome (CZS)
Overall design We identified the differentially expressed genes through transcriptome analyses between mock-infected and ZIKV-infected HTR8 cells and U251 cells, the ZIKV-infected group and the mock-infected group had three samples.
Contributor(s) Chen Q, Li N, Zeng S
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BioProject PRJNA883202
Submission date Jun 05, 2023
Last update date Jun 07, 2023
Contact name Qiqi Chen
Phone 15591822232
Organization name Sun Yat-sen University
Department School of Public Health (Shenzhen)
Street address Guangming District, Shenzhen City, Guangdong Province
City Shenzhen
State/province Guangdong Province
ZIP/Postal code 518107
Country China
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (12)
GSM7446509 HTR8_NF1
GSM7446510 HTR8_NF2
GSM7446511 HTR8_NF3

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE234128_genes_fpkm_expression.txt.gz 9.4 Mb (ftp)(http) TXT
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