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| Status |
Public on Aug 18, 2023 |
| Title |
RNA sequencing of an optimized shuttle cell line for intranasal delivery |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We generated cell lines from LX-2 hepatic stellate cells that are otpimzed for intranasal delivery of the oncolytic adenovirus XVir-N-31 to treat glioblastoma. One cell line migrates faster, the next in addition expressed HSV-TK as a safety gene to eliminate cells in case of adverse events.
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| Overall design |
RNA sequencing has been performed to analyze changes in gene expression between the parental (PAR) and the two optimized cell lines (FR and FR/TK). RNA sequencing was performed on mRNA generated from the three cell lines (n=3)
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| Web link |
https://doi.org/10.1002/1878-0261.13569
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| |
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| Contributor(s) |
Naumann U, Danielyan L, El-Ayoubi A, Arakelyan A |
| Citation(s) |
38115217 |
| |
| Submission date |
Jun 06, 2023 |
| Last update date |
Jan 13, 2024 |
| Contact name |
Ali El-Ayoubi |
| E-mail(s) |
alielayoubi88@gmail.com
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| Phone |
1514677940
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| Organization name |
Hertie Institute for Clinical Brain Research
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| Street address |
otfried müller straße 27
|
| City |
Tübingen |
| ZIP/Postal code |
72076 |
| Country |
Germany |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA980654 |
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