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| Status |
Public on Feb 07, 2024 |
| Title |
Co-enrichment of cancer-associated bacterial taxa is correlated with immune cell infiltrates in esophageal tumor tissue |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Rates of esophageal adenocarcinoma are rising globally, with risk factors including a range of genetic and environmental factors, including obesity, tobacco smoking, TP53 mutations, and Barrett’s esophagus, a proinflammatory condition which often occurs prior to developing adenocarcinoma. Interestingly, these factors also modulate the gastrointestinal microbiome. To better understand the linkage between the microbiome, inflammation, and development of esophageal adenocarcinoma, we integrated 16S and RNA sequencing data. We found several microbial taxa enriched in tumor samples which were correlated with predicted immune cell infiltration from RNA-seq data, including a decrease in megakaryocyte-erythroid progenitor cells with a concomitant increase in platelets. These data suggest dysbiosis of the intratumoral microbiome promotes development and production of platelets, which reveal alterations in the immune microenvironment of esophageal adenocarcinoma and suggest novel therapeutic targets.
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| Overall design |
49 esophageal normal and adenocarcinoma tissues
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| Contributor(s) |
Harris CC, Stone JK, Greathouse KL |
| Citation(s) |
38296990 |
| Submission date |
Jun 06, 2023 |
| Last update date |
Feb 07, 2024 |
| Contact name |
Joshua Stone |
| E-mail(s) |
josh.stone@nih.gov
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| Organization name |
NIH
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| Street address |
37 Convent Drive Room 3050
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| City |
Bethesda |
| State/province |
Maryland |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (44)
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| Relations |
| BioProject |
PRJNA980719 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE234304_raw_counts.csv.gz |
2.7 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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