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Series GSE234783 Query DataSets for GSE234783
Status Public on Jun 30, 2023
Title Functional identification of protocadherin alpha 9 (PCDHA9) as a candidate causative gene for amyotrophic lateral sclerosis
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Summary Genes associated with amyotrophic lateral sclerosis (ALS) are identified in ~15% of sporadic cases. Pcdh╬▒9 mouse mutants carrying the corresponding point mutation or deletion mutation manifested a progressive decline in survival and motor function (paralysis) caused by loss of spinal motor neurons, significant muscle atrophy, and structural/functional abnormalities of the neuromuscular junction. Potential causes of defects in mutant mice predicted by single nucleus RNA-seq and ATAC-seq.
Overall design scRNA-seq; snATAC-seq
Contributor(s) Zhang D, Zhong J, Wang C, Yao X
Citation(s) 38467605
Submission date Jun 13, 2023
Last update date Mar 20, 2024
Contact name Dan Zhang
Organization name Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Street address No. 1 West Beichen Road, Chaoyang District
City Beijing
ZIP/Postal code 100101
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM7474610 snATAC-seq of Mut
GSM7474611 snATAC-seq of WT
GSM7474612 snRNA-seq of Mut
BioProject PRJNA983211

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE234783_RAW.tar 395.1 Mb (http)(custom) TAR (of TAR)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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