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Series GSE234783 Query DataSets for GSE234783
Status Public on Jun 30, 2023
Title Functional identification of protocadherin alpha 9 (PCDHA9) as a candidate causative gene for amyotrophic lateral sclerosis
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Summary Genes associated with amyotrophic lateral sclerosis (ALS) are identified in ~15% of sporadic cases. Pcdh╬▒9 mouse mutants carrying the corresponding point mutation or deletion mutation manifested a progressive decline in survival and motor function (paralysis) caused by loss of spinal motor neurons, significant muscle atrophy, and structural/functional abnormalities of the neuromuscular junction. Potential causes of defects in mutant mice predicted by single nucleus RNA-seq and ATAC-seq.
 
Overall design scRNA-seq; snATAC-seq
 
Contributor(s) Zhang D, Zhong J, Wang C, Yao X
Citation(s) 38467605
Submission date Jun 13, 2023
Last update date Mar 20, 2024
Contact name Dan Zhang
E-mail(s) danzhang@genetics.ac.cn
Organization name Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Street address No. 1 West Beichen Road, Chaoyang District
City Beijing
ZIP/Postal code 100101
Country China
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM7474610 snATAC-seq of Mut
GSM7474611 snATAC-seq of WT
GSM7474612 snRNA-seq of Mut
Relations
BioProject PRJNA983211

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE234783_RAW.tar 395.1 Mb (http)(custom) TAR (of TAR)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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