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Status |
Public on Jul 14, 2023 |
Title |
Proviral location affects cognate peptide-induced virus production and immune recognition of 2 HIV-1-infected T cell clones |
Organism |
Homo sapiens |
Experiment type |
Other
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Summary |
In this study, we determined the effect of proviral inducibility on CD8+ T cell recognition of HIV-infected clones. We showed that a T cell clone containing a provirus integrated in relatively transcriptionally inactive site was much less recognized by CD8+ T cells than a T cell clone containing a provirus that was integrated into a trancriptionally active site.
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Overall design |
We compared the peripheral T cell receptor repertoire before and after chemoradiation in an elite controller with lung cancer. We also perfomed the functional expansion of specific T cells (FEST) assay to determine the repertoire of CD4+ T cells that responded to an HIV Gag peptide. *** Raw data files not provided due to sensitive nature of the data. ***
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Contributor(s) |
Dragoni F, Smith K, Simonetti F, Blankson J |
Citation(s) |
37698927 |
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Submission date |
Jul 07, 2023 |
Last update date |
Oct 16, 2023 |
Contact name |
Kellie Smith |
Organization name |
Johns Hopkins University
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Street address |
1550 Orleans St
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City |
Baltimore |
ZIP/Postal code |
21287 |
Country |
USA |
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Platforms (1) |
GPL32242 |
Illumina iSeq 100 (Homo sapiens) |
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Samples (12)
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Relations |
BioProject |
PRJNA992489 |