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| Status |
Public on Jul 14, 2023 |
| Title |
Proviral location affects cognate peptide-induced virus production and immune recognition of 2 HIV-1-infected T cell clones |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
In this study, we determined the effect of proviral inducibility on CD8+ T cell recognition of HIV-infected clones. We showed that a T cell clone containing a provirus integrated in relatively transcriptionally inactive site was much less recognized by CD8+ T cells than a T cell clone containing a provirus that was integrated into a trancriptionally active site.
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| Overall design |
We compared the peripheral T cell receptor repertoire before and after chemoradiation in an elite controller with lung cancer. We also perfomed the functional expansion of specific T cells (FEST) assay to determine the repertoire of CD4+ T cells that responded to an HIV Gag peptide.
*** Raw data files not provided due to sensitive nature of the data. ***
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| Contributor(s) |
Dragoni F, Smith K, Simonetti F, Blankson J |
| Citation(s) |
37698927 |
| |
| Submission date |
Jul 07, 2023 |
| Last update date |
Oct 16, 2023 |
| Contact name |
Kellie Smith |
| Organization name |
Johns Hopkins University
|
| Street address |
1550 Orleans St
|
| City |
Baltimore |
| ZIP/Postal code |
21287 |
| Country |
USA |
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| Platforms (1) |
| GPL32242 |
Illumina iSeq 100 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA992489 |
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