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Series GSE236931

Query DataSets for GSE236931

Status

Public on Sep 25, 2023

Title

Total RNA profiles of brain tissue in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology

Organism

Macaca nemestrina

Experiment type

Expression profiling by high throughput sequencing

Summary

Antiretroviral treatment regimens can effectively control HIV replication and some aspects of disease progression. However, molecular events in end-organ diseases such as central nervous system (CNS) disease are not yet fully understood, and routine eradication of latent reservoirs is not yet in reach. Regulatory RNAs have emerged as important participants in HIV disease pathogenesis. Using brain tissue from the simian immunodeficiency virus (SIV) model of HIV disease, we profiled messenger RNAs (mRNAs) and circular RNAs (circRNAs), seeking to identify possible networks of RNA interaction in SIV infection and neuroinflammation.

Overall design

Postmortem occipital cortex tissue were collected from pigtailed macaques: uninfected controls and SIV-infected subjects (acute phase and chronic phase with or without CNS pathology). RNAs from tissue were used for total RNA sequencing to detect mRNA and circRNA levels.

Contributor(s)

Witwer KW, Huang Y, Turchinovich A

Citation(s)

Submission date

Jul 10, 2023

Last update date

Dec 25, 2023

Contact name

Kenneth W. Witwer

E-mail(s)

kwitwer1@jhmi.edu

Phone

4109559770

Organization name

Johns Hopkins University School of Medicine

Department

Department of Molecular and Comparative Pathobiology

Street address

733 N. Broadway

City

Baltimore

State/province

MD

ZIP/Postal code

21205

Country

USA

Platforms (1)

Illumina NovaSeq 6000 (Macaca nemestrina)

Samples (38)

More...

GSM7585967	Rnase R untreated-Uninfected-BH-1
GSM7585968	Rnase R untreated-Uninfected-BH-2
GSM7585969	Rnase R untreated-Uninfected-BH-3

GSM7585970	Rnase R untreated-Uninfected-BH-4
GSM7585971	Rnase R untreated-Uninfected-BH-5
GSM7585972	RnaseR untreated-Acue-BH-1
GSM7585973	RnaseR untreated-Acue-BH-2
GSM7585974	RnaseR untreated-Acue-BH-3
GSM7585975	RnaseR untreated-Acue-BH-4
GSM7585976	RnaseR untreated-Acue-BH-5
GSM7585977	Rnase R untreated-Chronic infection without CNS pathology (CP-)-BH-1
GSM7585978	Rnase R untreated-Chronic infection without CNS pathology (CP-)-BH-3
GSM7585979	Rnase R untreated-Chronic infection without CNS pathology (CP-)-BH-4
GSM7585980	Rnase R untreated-Chronic infection without CNS pathology (CP-)-BH-5
GSM7585981	Rnase R untreated-Chronic infection without CNS pathology (CP-)-BH-6
GSM7585982	Rnase R untreated-Chronic infection without CNS pathology (CP-)-BH-7
GSM7585983	Rnase R untreated-Chronic infection with CNS pathology (CP+)-BH-1
GSM7585984	Rnase R untreated-Chronic infection with CNS pathology (CP+)-BH-2
GSM7585985	Rnase R untreated-Chronic infection with CNS pathology (CP+)-BH-4
GSM7585986	Rnase R treated-Uninfected-BH-1
GSM7585987	Rnase R treated-Uninfected-BH-2
GSM7585988	Rnase R treated-Uninfected-BH-3
GSM7585989	Rnase R treated-Uninfected-BH-4
GSM7585990	Rnase R treated-Uninfected-BH-5
GSM7585991	Rnase R treated-Acue-BH-1
GSM7585992	Rnase R treated-Acue-BH-2
GSM7585993	Rnase R treated-Acue-BH-3
GSM7585994	Rnase R treated-Acue-BH-4
GSM7585995	Rnase R treated-Acue-BH-5
GSM7585996	Rnase R treated-Chronic infection without CNS pathology (CP-)-BH-1
GSM7585997	Rnase R treated-Chronic infection without CNS pathology (CP-)-BH-2
GSM7585998	Rnase R treated-Chronic infection without CNS pathology (CP-)-BH-3
GSM7585999	Rnase R treated-Chronic infection without CNS pathology (CP-)-BH-5
GSM7586000	Rnase R treated-Chronic infection without CNS pathology (CP-)-BH-6
GSM7586001	Rnase R treated-Chronic infection without CNS pathology (CP-)-BH-7
GSM7586002	Rnase R treated-Chronic infection with CNS pathology (CP+)-BH-1
GSM7586003	Rnase R treated-Chronic infection with CNS pathology (CP+)-BH-2
GSM7586004	Rnase R treated-Chronic infection with CNS pathology (CP+)-BH-4

This SubSeries is part of SuperSeries:

RNA profiles of brain tissue

Relations

BioProject

Download family	Format
SOFT formatted family file(s)	SOFT
MINiML formatted family file(s)	MINiML
Series Matrix File(s)	TXT

Supplementary file	Size	Download	File type/resource
GSE236931_circRNA_circExp-raw_counts.xlsx	3.7 Mb	(ftp)(http)	XLSX
GSE236931_mRNA_Yiyao9_TMM_normalized_cpm_cdna_ncrna_121.xlsx	9.4 Mb	(ftp)(http)	XLSX
SRA Run Selector
Raw data are available in SRA
Processed data are available on Series record

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