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Status
Public on Aug 27, 2011
Title
Tofu decreases serum lipid levels and modulates hepatic gene expression involved in lipid metabolism in rats
Organism
Rattus norvegicus Experiment type
Expression profiling by array
Summary
The effects of freeze-dried tofu, a traditional Japanese soy food, were compared with those of major active soy components, protein and isoflavone, by observing physiological differences and global transcriptomes in the liver of male rats.
Overall design
Rats were randomly divided into 6 groups of 5 samples and assigned experimental diets for 14 days. The experimental diets were as follows: casein diet (C); C containing isoflavone (CI) soy protein diet (S); S containing isoflavone (SI); a diet containing 100 g/kg each of protein derived from casein and freeze-dried tofu (T10); a diet containing 200 g/kg of protein derived from freeze-dried tofu (T20). CI and SI were supplemented with a mixture of isoflavones to match the isoflavone level of T20.
Contributor(s)
Takahashi Y , Konishi T Citation(s)
21721588 Submission date
Aug 23, 2010
Last update date
Jul 31, 2017
Contact name
Tomokazu Konishi
E-mail(s)
konishi@akita-pu.ac.jp Phone
+81-18-872-1603
Organization name
Akita Prefectural University
Department
Bioresource Sciences
Lab
Molecular Genetics
Street address
Shimoshinjyo Nishi
City
Akita
State/province
Akita
ZIP/Postal code
010-0195
Country
Japan
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (30)
GSM586048 casein diet, biological rep4
GSM586049 casein diet, biological rep5
GSM586050 casein+isoflavone diet, biological rep1
GSM586051 casein+isoflavone diet, biological rep2
GSM586052 casein+isoflavone diet, biological rep3
GSM586053 casein+isoflavone diet, biological rep4
GSM586054 casein+isoflavone diet, biological rep5
GSM586055 soy protein diet, biological rep1
GSM586056 soy protein diet, biological rep2
GSM586057 soy protein diet, biological rep3
GSM586058 soy protein diet, biological rep4
GSM586059 soy protein diet, biological rep5
GSM586060 soy protein+isoflavone diet, biological rep1
GSM586061 soy protein+isoflavone diet, biological rep2
GSM586062 soy protein+isoflavone diet, biological rep3
GSM586063 soy protein+isoflavone diet, biological rep4
GSM586064 soy protein+isoflavone diet, biological rep5
GSM586065 casein + tofu diet, biological rep1
GSM586066 casein + tofu diet, biological rep2
GSM586067 casein + tofu diet, biological rep3
GSM586068 casein + tofu diet, biological rep4
GSM586069 casein + tofu diet, biological rep5
GSM586070 tofu diet, biological rep1
GSM586071 tofu diet, biological rep2
GSM586072 tofu diet, biological rep3
GSM586073 tofu diet, biological rep4
GSM586074 tofu diet, biological rep5
Relations BioProject
PRJNA130753
ANOVA header descriptions ID_REF probe set id
n the number of cells to be used in the ANOVA analysis
express P-values for afmong-group differences
cell:express P-values for the interactions between cell sensitivity and groups
Data table ID_REF n express cell:express 1367452_at
11
0.000237619
0.999348542
1367453_at
11
7.03E-08
0.976817475
1367454_at
11
0.008464597
0.19515684
1367455_at
11
1.39E-27
0.003487143
1367456_at
11
0.00036681
0.999998748
1367457_at
11
1.15E-14
0.995921146
1367458_at
11
0.004450241
0.80044332
1367459_at
11
1.29E-14
0.898714392
1367460_at
11
9.24E-09
1
1367461_at
11
3.95E-10
0.999999931
1367462_at
11
0.004222479
0.999830946
1367463_at
11
1.26E-13
0.999981552
1367464_at
11
5.25E-35
0.984976383
1367465_at
11
5.33E-34
0.985051737
1367466_at
11
6.30E-33
0.894557475
1367467_at
11
1.52E-16
0.583540708
1367468_at
11
0.000173332
0.999999994
1367469_at
11
0.002388446
0.999999955
1367470_at
11
6.10E-12
0.99977536
1367471_at
11
1.65E-35
0.995589344
31099 1094 Kbytes .Supplementary file Size Download File type/resource GSE23748_ANOVA_README.txt
1.1 Kb
(ftp) (http) TXT
GSE23748_RAW.tar
75.3 Mb
(http) (custom) TAR (of CEL)
Processed data included within Sample table Processed data are available on Series record
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