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Status |
Public on May 30, 2024 |
Title |
Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2- dependent transcription of Ifng |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencing Other
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Summary |
This SuperSeries is composed of the SubSeries listed below.
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Overall design |
Refer to individual Series
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Citation missing |
Has this study been published? Please login to update or notify GEO. |
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Submission date |
Jul 18, 2023 |
Last update date |
May 30, 2024 |
Contact name |
Xin Sun |
E-mail(s) |
sunxin@ifrec.osaka-u.ac.jp
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Organization name |
IFReC, Osaka University
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Street address |
3-1 Yamadaoka, Suita
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City |
Osaka |
ZIP/Postal code |
5650871 |
Country |
Japan |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (58)
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GSM7635036 |
WT_Sti, rep 1, ATACseq |
GSM7635037 |
WT_Sti, rep 2, ATACseq |
GSM7635038 |
WT_Sti, rep 3, ATACseq |
GSM7635039 |
KO_Ctl, rep 1, ATACseq |
GSM7635040 |
KO_Ctl, rep 2, ATACseq |
GSM7635041 |
KO_Ctl, rep 3, ATACseq |
GSM7635042 |
KO_Sti, rep 1, ATACseq |
GSM7635043 |
KO_Sti, rep 2, ATACseq |
GSM7635044 |
KO_Sti, rep 3, ATACseq |
GSM7635045 |
WT,GEX, L1 |
GSM7635046 |
WT,GEX, L2 |
GSM7635047 |
WT,GEX, L3 |
GSM7635048 |
WT,GEX, L4 |
GSM7635049 |
WT, ADT,L1 |
GSM7635050 |
WT, ADT,L2 |
GSM7635051 |
WT, ADT,L3 |
GSM7635052 |
WT, ADT,L4 |
GSM7635053 |
KO, GEX, L1 |
GSM7635054 |
KO, GEX, L2 |
GSM7635055 |
KO, GEX, L3 |
GSM7635056 |
KO, GEX, L4 |
GSM7635057 |
KO, ADT, L1 |
GSM7635058 |
KO, ADT, L2 |
GSM7635059 |
KO, ADT, L3 |
GSM7635060 |
KO, ADT, L4 |
GSM7635061 |
WT_Input, rep 1, ChIPseq |
GSM7635062 |
WT_Input, rep 2, ChIPseq |
GSM7635063 |
WT_ChIP, rep 1, ChIPseq |
GSM7635064 |
WT_ChIP, rep 2, ChIPseq |
GSM7635065 |
KO_Input, rep 1, ChIPseq |
GSM7635066 |
KO_Input, rep 2, ChIPseq |
GSM7635067 |
KO_ChIP, rep 1, ChIPseq |
GSM7635068 |
KO_ChIP, rep 2, ChIPseq |
GSM7635069 |
WT_Input, rep 3, ChIPseq |
GSM7635070 |
WT_ChIP, rep 3, ChIPseq |
GSM7635071 |
KO_Input, rep 3, ChIPseq |
GSM7635072 |
KO_ChIP, rep 3, ChIPseq |
GSM7635073 |
WT_Ctl, rep 1, RNAseq |
GSM7635074 |
WT_Ctl, rep 2, RNAseq |
GSM7635075 |
WT_Ctl, rep 3, RNAseq |
GSM7635076 |
WT_Sti, rep 1, RNAseq |
GSM7635077 |
WT_Sti, rep 2, RNAseq |
GSM7635078 |
WT_Sti, rep 3, RNAseq |
GSM7635079 |
KO_Ctl, rep 1, RNAseq |
GSM7635080 |
KO_Ctl, rep 2, RNAseq |
GSM7635081 |
KO_Ctl, rep 3, RNAseq |
GSM7635082 |
KO_Sti, rep 1, RNAseq |
GSM7635083 |
KO_Sti, rep 2, RNAseq |
GSM7635084 |
KO_Sti, rep 3, RNAseq |
GSM7635085 |
WT_NK |
GSM7635086 |
KO_NK |
GSM7635087 |
WT_tumor |
GSM7635088 |
KO_tumor |
GSM7846850 |
WT |
GSM7846851 |
KO |
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This SuperSeries is composed of the following SubSeries:
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GSE237637 |
The transcriptional landscape associated with the deletion of Regnase-1 [ATAC-Seq] |
GSE237639 |
Transcriptomic profile at single cell level of splenic NK cells from Reg-1fl/fl and Reg-1ΔNK mice [CITE-Seq] |
GSE237640 |
Identification of the genome-wide binding sites of OCT2 in Reg-1fl/fl- and Reg-1ΔNK-NK cells. [ChIP-Seq] |
GSE237641 |
The transcriptional landscape associated with the deletion of Regnase-1 [RNA-Seq] |
GSE237642 |
Transcriptomic profile at single cell level of TIL-NK cells and tumor cells from tumor-bearing Reg-1fl/fl and Reg-1ΔNK mice |
GSE245678 |
Transcriptomic profile at single cell level of OCT2fl/fl and Ncr(+)/OCT2fl/fl mice [scRNA-seq] |
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Relations |
BioProject |
PRJNA996077 |
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