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| Status |
Public on Aug 10, 2011 |
| Title |
Molecular studies on sex-different control of the hepatic metabolism in relations to insulin sensitivity (set 1) |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
In this study we have analyzed gene expression and metabolite levels in the livers of male and female Zucker diabetic fatty (ZDF) rats. We speculated that the sex different development of diabetes in the ZDF animals presents the opportunity to relate gender to diabetes (since only males become diabetic on normal diet). In this model one can search for parameters that distinguish females fed normal diet compared to high fat diet (i.e. components that vary with the development of diabetes) and evaluate if such changes can be related to components that characterize male diabetic animals..
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| Overall design |
Biological replicates: 4 ZDF female rat livers from rats on a standard diet (SD) and 4 ZDF female rat livers from rats on high-fat diet (HFD) (6 weeks). One replicate per array.
Hepatic gene expression, hepatic metabolites, sex-differences
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| Contributor(s) |
Gustavsson CE, Soga T, Norstedt G, Tollet-Egnell PE |
| Citation(s) |
21673048 |
| |
| Submission date |
Aug 25, 2010 |
| Last update date |
Mar 22, 2012 |
| Contact name |
Carolina Gustavsson |
| Organization name |
Karolinska institutet
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| Department |
Molecular medicine and surgery
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| Lab |
Molecular endocrinology
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| Street address |
CMM L8:01
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| City |
Stockholm |
| ZIP/Postal code |
17176 |
| Country |
Sweden |
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| Platforms (1) |
| GPL6528 |
Rat Oligo array V3.0.5 27648 spots |
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| Samples (4)
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| GSM587263 |
Female ZDF rats on SD vs female ZDFrat on HFDarray 11 |
| GSM587264 |
Female ZDF rats on SD vs female ZDFrat on HFDarray 12 |
| GSM587265 |
Female ZDF rats on HFD vs female ZDFrat on SDarray 15 |
| GSM587266 |
Female ZDF rats on SD vs female ZDFrat on HFDarray 16 |
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| This SubSeries is part of SuperSeries: |
| GSE23810 |
Molecular studies on sex-different control of the hepatic metabolism in relations to insulin sensitivity |
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| Relations |
| BioProject |
PRJNA133163 |
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