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Series GSE238266 Query DataSets for GSE238266
Status Public on Feb 27, 2024
Title Identification of expression patterns of FoxP1 in the kidneys using RiboTag mice and RNA sequencing
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Intercalated cells within renal tubules play a vital role in maintaining body acid-base balance through H+ and HCO3- secretion. Disruptions in intercalated cell differentiation or channel activity due to gene mutations can lead to distal renal tubular acidosis (dRTA), yet the precise mechanisms governing this process remain poorly understood. This study identified Foxp1 and its downstream factors as novel essential factors for intercalated cell differentiation, thus shed light on potential underlying mechanisms in some unresolved cases of dRTA.
Overall design To investigate the role of Foxp1 in kidney collecting tube, we generated the Cdh16-cre;Foxp1fl/fl (thereafter denoted as FoxP1kspKO) by crossing the Foxp1fl/fl mice with the Cdh16-Cre (also known as the Ksp-Cre) mice. In these mice, FoxP1 is conditionally knocked out in kidney tubular cells and the absence Foxp1 expression in kidney tubular cells was confirmed by immunostaining.
Contributor(s) Wu S, Lu D, Feng Y, Song R
Citation(s) 38332484
Submission date Jul 26, 2023
Last update date Mar 06, 2024
Contact name RENHUA SONG
Phone 61452667663
Organization name Centenary Institute
Lab Epigenetics and RNA Biology Program
Street address Charles Perkins Centre - D17, Level 4 West. The University of Sydney Johns Hopkins Drive
City Camperdown
State/province NSW
ZIP/Postal code 2050
Country Australia
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (6)
GSM7661283 Kidney, neonatal littermate control 1
GSM7661284 Kidney, neonatal littermate control 2
GSM7661285 Kidney, neonatal littermate control 3
This SubSeries is part of SuperSeries:
GSE238268 Foxp1 is required for renal intercalated cell differentiation and acid-base regulation
BioProject PRJNA998705

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Supplementary file Size Download File type/resource
GSE238266_RAW.tar 73.8 Mb (http)(custom) TAR (of BW)
GSE238266_counts_uniq.txt.gz 3.5 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record
Processed data provided as supplementary file

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