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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jul 21, 2011 |
| Title |
Genomic Profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage (mammary normal and tumors in different mice strains) |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
MicroRNAs (miRNAs) are small, non-coding, endogenous RNAs involved in many human diseases including breast cancer. miRNA expression profiling of human breast cancers has identified miRNAs related to the clinical diversity of the disease and potentially provides novel diagnostic and prognostic tools for breast cancer therapy. In order to further understand the roles of miRNAs in association with oncogenic drivers and in specifying sub-types of breast cancer, we performed miRNAexpression profiling on mammary tumors from eight well-characterized genetically -engineered Mouse (GEM) models of human breast cancer including MMTV–H-Ras, -Her2/neu, -c-Myc, -PymT, –Wnt1 and C3(1)/SV40 T/t-antigen transgenic mice, BRCA1fl/fl;p53+/-;MMTV-cre and the p53fl/fl ;MMTV-cre transplant model.
As supplementary data
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| Overall design |
miRNA expression data for 3 mouse primary mammary tumors and 8 mouse normal mammary glands from different mouse strains
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| Contributor(s) |
Zhu M, Yi M, Kim CH, Deng C, Li Y, Medina D, Stephen R, Green J |
| Citation(s) |
21846369 |
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| Submission date |
Sep 03, 2010 |
| Last update date |
Mar 22, 2012 |
| Contact name |
Jeffrey E Green |
| E-mail(s) |
JEGreen@mail.nih.gov
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| Phone |
3014355193
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| Fax |
3014968709
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| Organization name |
NCI
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| Street address |
Rm 4054, 37 Convent Drive
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA130465 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE23977_RAW.tar |
2.3 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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