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| Status |
Public on Dec 22, 2023 |
| Title |
eIF3B CLIP-sequencing in prostate cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The role of eIF3B in advanced therapy resistant lethal stages of prostate cancer remains unknown. To gain insight into how eIF3B regulates the translation of specific mRNAs we performed Genome-wide eIF3B enhanced cross-linking immunoprecipitation sequencing (eCLIP-seq). this analysis showed specialized binding to a UC-rich motif present in subsets of 5’-UTRs. Indeed, translation of the androgen receptor (AR) and major histocompatibility complex I (MHC-I) through this motif are sensitive to eIF3B amount. These results suggest that eIF3B by regulating specific mRNA translation may play key role in the pathogenesis of lethal prostate cancer.
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| Overall design |
eIF3B eCLIP-Seq in human prostate cancer cell line 22Rv1
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| Contributor(s) |
Santasusagna S, Zhu S, Jawalagatti V, Domingo-Domenech J, Hassan A |
| Citation(s) |
37676710 |
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| Submission date |
Aug 08, 2023 |
| Last update date |
Feb 08, 2024 |
| Contact name |
Yujin Hoshida |
| Organization name |
University of Texas Southwestern Medical Center
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| Street address |
5323 Harry Hines Blvd
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| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390 |
| Country |
USA |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA1003405 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE240338_RAW.tar |
214.9 Mb |
(http)(custom) |
TAR (of BW) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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