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| Status |
Public on Sep 29, 2023 |
| Title |
Transcriptional profiling of male PAB rats with compensated and decompensated right ventricule |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We performed molecular phenotyping of adaptive to maladaptive RV hypertrophy remodeling, using transcriptome analysis of RV tissue obtained from PAB rats. This data along with other datasets linked within this study, provides a resource to comprehensively compare human RV remodeling to the animal RV dysfunction models (PAB) and led to the validation of state-specific biomarkers and potential therapeutic targets for RV dysfunction.
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| Overall design |
RNA sequencing was performed for RV tissues obtained from PAB rats which were characterized as compensated RV, decompensated RV by hemodynamics, as well as normal RV from control rats, including only male samples as follows: control (n=5), compensated RV (n=5), decompensated RV (n=4)
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| Web link |
https://doi.org/10.1038/s44161-023-00338-3
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| Contributor(s) |
Khassafi F, Chelladurai P, Bonnet S, Pullamsetti SS |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Aug 31, 2023 |
| Last update date |
Sep 29, 2023 |
| Contact name |
Fatemeh Khassafi |
| E-mail(s) |
s.khassafi92@gmail.com
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| Organization name |
Max Planck Institute
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| Lab |
Soni Pullamsetti
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| Street address |
Parkstrasse
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| City |
Bad Nauheim |
| ZIP/Postal code |
61231 |
| Country |
Germany |
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| Platforms (1) |
| GPL32190 |
NextSeq 2000 (Rattus norvegicus) |
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| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE240941 |
Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension |
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| Relations |
| BioProject |
PRJNA1011206 |
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