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| Status |
Public on Feb 28, 2024 |
| Title |
Dynamic and distinct histone modifications facilitate human trophoblast lineage specification |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
The placenta serves as an essential organ for nurturing fetal growth throughout pregnancy. Histone modification is a crucial regulatory mechanism involved in numerous biological processes and development. Nevertheless, there remains a significant gap in our understanding regarding the precise mechanisms and extent to which various histone modifications influence the critical process of trophoblast lineage differentiation, which is fundamental to placental development. Here, we conducted a comprehensive mapping of H3K4me3, H3K27me3, H3K9me3, and H3K27ac loci during trophoblast stem cells (TSC) differentiation into syncytiotrophoblasts (ST) and extravillous trophoblasts (EVT) to investigate the regulatory roles and dynamic changes in histone modifications in trophoblast lineage specification.
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| Overall design |
ChIP-seq were performed for various histone modfication (H3K4me3, H3K27me3, and H3K9me3, and H3K27ac) in human trophoblast stem (TS) cells, cyncytiotrophoblat, Extravillous trophoblast. Input was sequenced for a control.
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| Contributor(s) |
Lee B |
| Citation(s) |
38402275 |
| |
| Submission date |
Sep 13, 2023 |
| Last update date |
Feb 28, 2024 |
| Contact name |
Bum-Kyu Lee |
| E-mail(s) |
blee6@albany.edu
|
| Phone |
5185917231
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| Organization name |
University of Albany-SUNY
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| Street address |
One Discovery Drive, Cancer Research Center, RM332
|
| City |
Rensselaer |
| State/province |
New York |
| ZIP/Postal code |
12144 |
| Country |
USA |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA1016306 |
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