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Series GSE243120 Query DataSets for GSE243120
Status Public on May 14, 2024
Title T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis [MERFISH]
Platform organism synthetic construct
Sample organism Mus musculus
Experiment type Other
Summary Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease (AD) remains uncertain, despite age being a major risk factor. Using a mouse model of AD, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.
Overall design Brain sections were collected from mouse model of amyloidosis and analyzed by MERFISH
Contributor(s) Androvic P, Gokce O
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Submission date Sep 13, 2023
Last update date May 15, 2024
Contact name Peter Androvic
Organization name LMU Hospital, Institute for Stroke and Dementia Research
Lab Gokce Lab
Street address Feodor-Lynen-Strasse 17
City Munich
State/province Bavaria
ZIP/Postal code 81377
Country Germany
Platforms (1)
Samples (5)
GSM7779544 Animal 1, section 1, MERFISH
GSM7779545 Animal 1, section 2, MERFISH
GSM7779546 Animal 2, section 1, MERFISH
BioProject PRJNA1016407

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE243120_MERFISH_5xFAD_expression.txt.gz 45.2 Mb (ftp)(http) TXT
GSE243120_MERFISH_5xFAD_metadata.txt.gz 6.3 Mb (ftp)(http) TXT
GSE243120_RAW.tar 5.5 Gb (http)(custom) TAR (of CSV)

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