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| Status |
Public on May 14, 2024 |
| Title |
T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis [MERFISH] |
| Platform organism |
synthetic construct |
| Sample organism |
Mus musculus |
| Experiment type |
Other
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| Summary |
Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.
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| Overall design |
Brain sections were collected from mouse model of amyloidosis and analyzed by MERFISH
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/38937583/
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| Contributor(s) |
Androvic P, Gokce O |
| Citation(s) |
38937583 |
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| Submission date |
Sep 13, 2023 |
| Last update date |
Aug 14, 2024 |
| Contact name |
Peter Androvic |
| Organization name |
LMU Hospital, Institute for Stroke and Dementia Research
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| Lab |
Gokce Lab
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| Street address |
Feodor-Lynen-Strasse 17
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| City |
Munich |
| State/province |
Bavaria |
| ZIP/Postal code |
81377 |
| Country |
Germany |
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| Platforms (1) |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA1016407 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE243120_MERFISH_5xFAD_expression.txt.gz |
45.2 Mb |
(ftp)(http) |
TXT |
| GSE243120_MERFISH_5xFAD_metadata.txt.gz |
6.3 Mb |
(ftp)(http) |
TXT |
| GSE243120_RAW.tar |
5.5 Gb |
(http)(custom) |
TAR (of CSV) |
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