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Series GSE243374 Query DataSets for GSE243374
Status Public on Feb 29, 2024
Title Serum exosomal miRNA profile in pregnancies with gestational diabetes based on pancreatic β-cell function
Platform organism synthetic construct
Sample organism Homo sapiens
Experiment type Expression profiling by array
Summary Pancreatic β-cell function impairment is a key mechanism for developing gestational diabetes mellitus (GDM). Maternal and placental exosomes regulate maternal and placental responses during hyperglycemia. Studies have associated exosomal micro RNAs (miRNAs) with GDM development. To date, no studies have been reported that evaluate the profile of miRNAs present in maternal and placental exosomes in the early stages of gestation from pregnancies that develop GDM.
We used microarrays to assess whether early pregnancy maternal and placental exosomal miRNA profiles vary according to pancreatic β-cell function in women who will develop GDM (preGDM).
Overall design A prospective nested case-control study was used to identify exosomal miRNAs that vary in early pregnancy stages (<18 weeks of gestation) from women with normoglycemia and those that developed GDM based on their pancreatic β-cell function using HOMA-%β index. Early pregnancy maternal and placental serum exosomes were isolated to obtain miRNA profiles.
Contributor(s) Razo-Azamar M, Palacios-González B
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Submission date Sep 15, 2023
Last update date Feb 29, 2024
Contact name Melissa Razo-Azamar
Phone 0450481814
Organization name Instituto Nacional de Medicina Genómica (INMEGEN)
Department Centro de Investigación sobre el Envejecimiento
Lab Laboratorio de Envejecimiento Saludable
Street address Calz. de los Tenorios 235 Col. Rinconada de las Hadas, Alcaldía Tlalpan, Ciudad de México
City Mexico City
ZIP/Postal code 4330
Country Mexico
Platforms (1)
GPL21572 [miRNA-4] Affymetrix Multispecies miRNA-4 Array [ProbeSet ID version]
Samples (28)
GSM7784444 MAT control_low_HOMA%β_index_pool1
GSM7784445 MAT control_low_HOMA%β_index_pool2
GSM7784446 MAT control_low_HOMA%β_index_pool4
BioProject PRJNA1017902

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Supplementary file Size Download File type/resource
GSE243374_RAW.tar 26.1 Mb (http)(custom) TAR (of CEL, CHP)

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