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| Status |
Public on Apr 30, 2024 |
| Title |
Single-nucleus Transcriptomics Reveals Cardiac Cell Type-specific Diversification in Metabolic Disease Transgenic Pigs |
| Organism |
Sus scrofa |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Cardiac injury triggered by early metabolic disease is poorly investigated due to the complexity of pathophysiology. We comprehensively reveal the cellular landscape of healthy and metabolically disturbed heart through single-nucleus RNA sequencing, using the metabolic disease-susceptible transgenic pig model as material.
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| Overall design |
We performed single-nucleus RNA sequencing on left ventricular myocardium from both triple-transgenic pig(PNPLA3I148M-GIPRdn-hIAPP) (TG) and wild-type pig (WT).
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| Contributor(s) |
Miao J, Zhang K, Yang Y, Yang S |
| Citation(s) |
38868189 |
| |
| Submission date |
Oct 16, 2023 |
| Last update date |
Jun 28, 2024 |
| Contact name |
Jiakun Miao |
| E-mail(s) |
miaojiakun0225@gmail.com
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| Organization name |
Chinese Academy of Agricultural Sciences
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| Department |
Institute of Animal Science
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| Lab |
State Key Laboratory of Animal Biotech Breeding
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| Street address |
No. 2 Yuanmingyuan West Road
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| City |
Beijing |
| ZIP/Postal code |
100000 |
| Country |
China |
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| Platforms (1) |
| GPL22475 |
Illumina HiSeq 4000 (Sus scrofa) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA1028552 |
