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| Status |
Public on Feb 08, 2024 |
| Title |
LMO3 is a suppressor of the basal-like/squamous PDAC subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Pancreatic cancer is a heterogenous disease and consists of distinct subtypes. Here, we searched for candidate suppressor genes of the basal-like/squamous subtype, a more aggressive molecular subtype of pancreatic ductal adenocarcinoma (PDAC). Through an integrated transcriptome analysis, we identified the LMO3, as being downregulated in the basal-like/squamous PDAC using a discovery and validation approach. LMO3 downregulation associated with decreased patient survival. The goal of this study was aimed to identify LMO3 induced molecular signatures in PDAC.
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| Overall design |
RNA was isolated from PDAC cell lines (n = 8 Panc 10.05_Ctrl vs LMO3) using TRIzol method. The mRNA profiles of the above human PDAC cell lines were generated by deep sequencing using Illumina NextSeq.
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| Contributor(s) |
Yuuki O, Amanda J. C, Huaitian L, Shouhui Y, Paloma M, Tiffany H. D, Helen C, Azadeh A, Jochen G, Michael G, Nader H, Stefan A, S Perwez H |
| Citation(s) |
38366633 |
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| Submission date |
Oct 31, 2023 |
| Last update date |
Apr 30, 2024 |
| Contact name |
Stefan Ambs |
| E-mail(s) |
ambss@mail.nih.gov
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| Phone |
240-760-6836
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| Organization name |
NCI
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| Department |
CCR
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| Lab |
LHC
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| Street address |
Building 37, Room 3050B
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892-4258 |
| Country |
USA |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA1034082 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE246660_RawCountFile_rsemgenes_LMO3.txt.gz |
765.1 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
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