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| Status |
Public on Mar 21, 2024 |
| Title |
DNA methylation alterations across time and space in paediatric brain tumours |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
DNA methylation is increasingly used for tumour classification and has expanded upon the > 100 currently known brain tumour entities. A correct diagnosis is the basis for suitable treatment for patients with brain tumours, which is the leading cause of cancer-related death in children. DNA methylation profiling is required for diagnosis of certain tumours, and used clinically for paediatric brain tumours in several countries. We therefore evaluated if the methylation-based classification is robust in different locations of the same tumour, and determined how the methylation pattern changed over time to relapse.
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| Overall design |
We sampled 3-7 spatially separated biopsies per patient, and collected samples from paired primary and relapse brain tumours from children. Altogether, 121 samples from 46 paediatric patients with brain tumours were profiled with EPIC methylation arrays.
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| Contributor(s) |
Wenger A, Ferreyra Vega S, Carén H |
| Citation(s) |
35842717 |
| |
| Submission date |
Nov 15, 2023 |
| Last update date |
Mar 22, 2024 |
| Contact name |
Helena Carén |
| E-mail(s) |
helena.caren@gu.se
|
| Organization name |
University of Gothenburg
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| Street address |
Medicinaregatan 1F
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| City |
Gothenburg |
| ZIP/Postal code |
41390 |
| Country |
Sweden |
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| Platforms (1) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA1040863 |
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