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| Status |
Public on Jun 04, 2024 |
| Title |
Whole RNA profiling of Tuberculosis-diabetes comorbidity linked to diabetes with poor glycemic control |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Type 2 diabetes (DM2) is a disease that hinders tuberculosis (TB) control strategies worldwide. TB infection, progression, morbidity, treatment success, adverse effects, relapse, and mortality are worse in these susceptible populations. Therefore, expanding the partially known molecular mechanisms leading to TB-DM2 comorbidity may be essential to face both epidemics. Consequently, a transcriptomic study was conducted on TB-DM2 comorbidity, associated with patients with DM2 who have poor glycaemic control (PDM2), since they have a higher risk of getting TB. Human blood samples from healthy controls (CTRL, HbA1c < 6.5%), TB ( HbA1c < 6.5%), TB-DM2, DM2 (HbA1c < 8.9%), and PDM2 (HbA1c > 10%) groups (n=4 each) were analyzed using high-density human GE 4X44K v2 differential expression microarrays.
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| Overall design |
Human blood samples from healthy controls (CTRL, HbA1c < 6.5%), TB (HbA1c < 6.5%), TB-DM2 (HbA1c>6.5%), DM2 (HbA1c 6.5-8.9%), and PDM2 (HbA1c > 10%) groups (n=4 each) were analyzed using high-density human GE 4X44K v2 differential expression microarrays.
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| Contributor(s) |
Jaime-Sánchez E, Lara-Ramírez EE, López-Ramos JE, Ramos-González EJ, Cisneros-Méndez AL, Oropeza-Valdez JJ, Zenteno-Cuevas R, Martínez-Aguilar G, Bastian Y, Castañeda-Delgado JE, Serrano CJ, Enciso-Moreno JA |
| Citation(s) |
38801463 |
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| Submission date |
Nov 30, 2023 |
| Last update date |
Jun 05, 2024 |
| Contact name |
José Antonio Enciso-Moreno |
| E-mail(s) |
enciso_2000@yahoo.com
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| Organization name |
Instituto Mexicano del Seguro Social
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| Department |
Unidad de Investigación Biomédica de Zacatecas
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| Lab |
Unidad de Investigación Biomédica de Zacatecas
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| Street address |
Interior de la Alameda 45
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| City |
Zacatecas |
| State/province |
Zacatecas |
| ZIP/Postal code |
98000 |
| Country |
Mexico |
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| Platforms (1) |
| GPL10332 |
Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Feature Number version) |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA1047166 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE249102_Normalized_signal_intensity_AverExp_of_446genes.txt.gz |
47.4 Kb |
(ftp)(http) |
TXT |
| GSE249102_RAW.tar |
47.9 Mb |
(http)(custom) |
TAR (of TXT) |
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