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| Status |
Public on Dec 06, 2023 |
| Title |
Changes in cognitive ability and serum microRNAs during aging in mice |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Mild cognitive impairment (MCI) is considered an early stage leading to dementia. MCI can be reversed, and early diagnosis at the MCI stage is vital to control the progression to dementia. Dementia is currently diagnosed based on interviews and screening tests. However, novel biomarkers must be identified to enable early detection of MCI. Therefore, this study aimed to discover novel biomarkers in the form of blood microRNAs (miRNAs) for the diagnosis of MCI or early dementia.
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| Overall design |
Four-week-old (4w), 8-week-old (8w), 36-week-old (36w) and 58-week-old (58w) mice were used in this study (each n = 4). In this study, mice of various ages were used to search for microRNAs whose expression changes in serum with aging.
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| Contributor(s) |
Chiba M, Yamamoto K |
| Citation(s) |
38361521 |
| |
| Submission date |
Dec 04, 2023 |
| Last update date |
Feb 26, 2024 |
| Contact name |
Mitsuru Chiba |
| E-mail(s) |
mchiba32@hirosaki-u.ac.jp
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| Phone |
+81172395965
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| Organization name |
Hirosaki University
|
| Department |
Graduate School of Health Sciences
|
| Lab |
Department of Bioscience and Laboratory Medicine
|
| Street address |
66-1 Hon-cho
|
| City |
Hirosaki |
| State/province |
Aomori |
| ZIP/Postal code |
036-8564 |
| Country |
Japan |
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| Platforms (1) |
| GPL22383 |
Agilent-070155 Mouse miRNA Microarray (Feature Extraction Number version) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA1048312 |
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