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Series GSE249636 Query DataSets for GSE249636
Status Public on Mar 25, 2024
Title Phenotypical states modulate sensitivity and transcriptional reprogramming in patient-derived glioblastoma cells in response to temozolomide and radiation therapy. [array]
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Genome wide DNA methylation profiling of patient-derived glioblastoma cells cultured as neurospheres or FBS differentited cells. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in glioblastoma CSCs and serum differentiated cells treated with 4 Gy ionizing radiation or IC30 concentration of temozolomide as well as vehicle control samples. Samples included 3 technical replicates in each treatment group for 2 primary glioblastoma cell lines.
 
Overall design Bisulphite converted DNA from the 36 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip
 
Contributor(s) Nuga O, Berezovsky A, Dutta I, Bergman K, Sabedot T, Gurdziel K, Irtenkauf S, Hasselbach L, Meng Y, Mueller C, Petricoin III EF, Brown S, Aras S, Poisson L, Noushmehr H, Ruden D, deCarvalho AC
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Submission date Dec 07, 2023
Last update date Mar 26, 2024
Contact name oluwademilade Nuga
E-mail(s) demialloneword@gmail.com
Organization name Wayne State University
Department Pharmacology
Lab deCarvalho/Todi lab
Street address 540 E canfield
City Detroit
State/province MI
ZIP/Postal code 48239
Country USA
 
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (36)
GSM7956516 genomic DNA from CSC HF2303 control sample replicate 1
GSM7956517 genomic DNA from CSC HF2303 control sample replicate 2
GSM7956518 genomic DNA from CSC HF2303 control sample replicate 3
This SubSeries is part of SuperSeries:
GSE249637 Phenotypical states modulate sensitivity and transcriptional reprogramming in patient-derived glioblastoma cells in response to temozolomide and radiation therapy.
Relations
BioProject PRJNA1049856

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE249636_RAW.tar 476.2 Mb (http)(custom) TAR (of IDAT)

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