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| Status |
Public on Apr 18, 2024 |
| Title |
Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension governs right ventricle remodeling and recovery [ext327_rnaseq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The present prospective study included a total number of 3 patients with a final diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH), who were treated by pulmonary endarterectomy (PEA) at the Kerckhoff Heart and Thorax Center between 2016 and 2020.
Biopsies of the myocardial interventricular septum from 3 patients were collected at baseline (BL) before PEA surgery (pre-septal-PEA)
In this case, to account for technical and safety aspects, the specimens were taken from the myocardial interventricular septum.
The aim of the Study was a comparative characterization of RNA-profiles of septum in CTEPH patients after PEA surgery (postPEA) compared to before PEA surgery (pre-septal-PEA).
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| Overall design |
Confirmatory cohort:
Comparison of RNA profile of CTEPH patients: pre-septal-PEA (n=3) with their corrsponding postPEA (n=3) specimens
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| Contributor(s) |
Liebetrau C, Pullamsetti S, Mayer E, Dorfmüller P, Jafari L, Troidl C, Guenther S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 08, 2023 |
| Last update date |
Apr 18, 2024 |
| Contact name |
Carsten Kuenne |
| E-mail(s) |
Carsten.Kuenne@mpi-bn.mpg.de
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| Organization name |
Max Planck Institute for Heart and Lung Research
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| Department |
Bioinformatics
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| Street address |
Ludwigstrasse 43
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| City |
Bad Nauheim |
| ZIP/Postal code |
61231 |
| Country |
Germany |
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| Platforms (1) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE249697 |
Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension governs right ventricle remodeling and recovery |
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| Relations |
| BioProject |
PRJNA1050207 |
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