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| Status |
Public on Mar 09, 2012 |
| Title |
microRNA alterations associated to clinical response in advanced stage ovarian cancer patients (test set) |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
In order to investigate miRNA alterations associated to early relapse in ovarian cancer patietns, we analyzed miRNA expression profile in a test set of 30 surgical specimens including 13 early and 17 late relapsing patients. Samples included in test set were obtained from formalin-fixed paraffin-embedded (FFPE) specimens.
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| Overall design |
Patients were selected on the basis of residual disease after primary surgery and time to relapse (TTR) after front-line chemotherapy. For the test set, a selection of the outliers concerning TTR was made: 12 months from the end of therapy was the TTR selected to define early (<12 months) or late (>12 months) relapsing patients.
Clinical codes:
Histotype: according to International Federation of Gynecological and Obstetrics guidelines
Stage: according to International Federation of Gynecological and Obstetrics guidelines
Grading: according to WHO guidelines
Debulking: NED: not evident disease; mRD: minimal residual disease; GRD: gross residual disease
Therapy code: P: Platinum without taxanes; PT: Platinum/paclitaxel
End Point: Early: relapse whithin 12 and 6 months from the end of therapy for optimally (NED+ mRD) and sub-optimally (GRD) debulked patients respectively. Late: median time to relapse 48 and 34 months from the end of therapy for optimally and sub-optimally debulked patients respectively.
Time to relapse (TTR) code: 0=no relapse; 1=relapse
Overall survival (OS) code: 0=alive; 1=dead
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| Contributor(s) |
De Cecco L |
| Citation(s) |
22246208 |
| |
| Submission date |
Nov 08, 2010 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Loris De Cecco |
| E-mail(s) |
loris.dececco@istitutotumori.mi.it
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| Organization name |
IRCSS Istituto Nazionale Tumori
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| Street address |
via Venezian 1
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| City |
Milan |
| ZIP/Postal code |
20133 |
| Country |
Italy |
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| Platforms (1) |
| GPL8179 |
Illumina Human v2 MicroRNA expression beadchip |
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| Samples (30)
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| This SubSeries is part of SuperSeries: |
| GSE25204 |
microRNA alterations associated to clinical response in advanced stage ovarian cancer patients |
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| Relations |
| BioProject |
PRJNA142791 |
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