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| Status |
Public on Apr 26, 2024 |
| Title |
The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [MeDIP] |
| Organism |
Rattus norvegicus |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
Background. Prenatal exposure to nicotine has been documented to impose numerous deleterious effects on fetal development. However, the epigenetic changes promoted by nicotine exposure on germ cell are still not well understood. Objectives. In this study, we focused on elucidating the impact of prenatal nicotine exposure on regulatory epigenetic mechanisms important for the germ cells development. s important for the germ cells development
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| Overall design |
Sprague-Dawley rats were exposed to nicotine during pregnancy and male progeny was analyzed at age of 11 weeks. A genome-wide DNA methylation was analyzed using MEDIP-seq.
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| Contributor(s) |
Smagulova F |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 18, 2024 |
| Last update date |
Apr 27, 2024 |
| Contact name |
Fatima SMAGULOVA |
| E-mail(s) |
fatima.smagulova@inserm.fr
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| Phone |
+3323233662
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| Organization name |
Irset - U1085
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| Lab |
Chromatin, Epigenetics, Environment
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| Street address |
9 av. Prof. Léon Bernard
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| City |
Rennes |
| ZIP/Postal code |
35000 |
| Country |
France |
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| Platforms (1) |
| GPL32190 |
NextSeq 2000 (Rattus norvegicus) |
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| Samples (7)
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| This SubSeries is part of SuperSeries: |
| GSE253596 |
The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat |
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| Relations |
| BioProject |
PRJNA1066336 |
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