NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE254271 Query DataSets for GSE254271
Status Public on Jul 19, 2024
Title Expression data from S100A9 and HMGB1 treated human CD14+ monocytes
Organism Homo sapiens
Experiment type Expression profiling by array
Summary TLR4 signaling was reported to be involved in the upregulation of PD-L1 expression and induction of immunosuppressive properties of human CD14+ monocytes. Damage associated molecular patterns (DAMPs) S100A8, A9, and HMGB1, which act as endogenous TLR4 ligands, drive MDSC activation and were shown to be markedly expressed in the tumor microenvironment (TME) of solid tumors.
The role of S100A8/9 and HMGB1 in the acquisition of MDSC immunosuppressive activity remains to be better defined.
 
Overall design CD14+ monocytes were treated with recombinant (r) S100A9 and HMGB1 in the presence of GM-CSF with or without FPS-ZM1 or TAK-242 for 72 h. Monocytes were also stimulated with GM-CSF only for 72h (Control). After 72h, total RNA was isolated from monocytes and gene expression profiling was performed.
 
Contributor(s) Özbay Kurt FG, Delatorre C
Citation(s) 39266214
Submission date Jan 25, 2024
Last update date Oct 09, 2024
Contact name Carolina Delatorre
E-mail(s) carolina.delatorre@medma.uni-heidelberg.de
Organization name University Heidelberg
Street address Theodor-Kutzer-Ufer 1-3
City Mannheim
ZIP/Postal code 68167
Country Germany
 
Platforms (1)
GPL34133 [Clariom_S_Human] Affymetrix Clariom S Assay, Human [CDF: Brainarray ClariomSHuman_Hs_ENTREZG_25.0.0]
Samples (28)
GSM8037072 GM-CSF treated mono, biological replicate 1
GSM8037073 GM-CSF treated mono, biological replicate 2
GSM8037074 GM-CSF treated mono, biological replicate 3
Relations
BioProject PRJNA1069113

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE254271_RAW.tar 34.6 Mb (http)(custom) TAR (of CEL)

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap