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| Status |
Public on Apr 29, 2024 |
| Title |
Expression data from mice cortical microglia and astrocytes. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Functional recruitment of microglia depends on OXPHOS in vivo. OXPHOS upregualtion correlates with phagocytic activity of microglia in physiologycal conditions and with proinflammatory microglia in pathological conditions.
We used microarrays to detail the global programme of gene expression underlying loss of mitochondrial Complex I in microglia cells and its impact in astrocytes gene expression.
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| Overall design |
Mice brains were dissected to use the whole cortex for isolation of micrgolia and astrocytes by fluorescence-activated cell sorting (FACS) (microglia: CD11b + CD45 postive cells; astrocytes: ACSA2 positive cells).
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| Contributor(s) |
Pérez-Moreno JJ, Mora-Romero B, Álvarez-Vergara MI, Pascual A |
| Citation(s) |
39048800 |
| |
| Submission date |
Jan 30, 2024 |
| Last update date |
Jul 27, 2024 |
| Contact name |
Juan Jose Perez-Moreno |
| E-mail(s) |
jpmoreno@us.es
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| Organization name |
University of Seville
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| Department |
Cell Biology
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| Street address |
Instituto de Biomedicina de Sevilla (IBiS), Campus Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot
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| City |
Seville |
| ZIP/Postal code |
41013 |
| Country |
Spain |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (29)
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| Relations |
| BioProject |
PRJNA1071087 |
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