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Series GSE260909 Query DataSets for GSE260909
Status Public on Mar 27, 2024
Title Exosomal miRNA profiling in Bcl-w overexpressed U251cells
Platform organism synthetic construct
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Exosomes are cell membrane-derived endoplasmic reticulum measuring 30 to 120 nm, which are secreted from various cells including cancer cells, and consist of lipids, proteins, mRNAs, and microRNAs (miRNAs). Tumor-derived exosomes are involved in tumor progression by delivering various factors to neighboring cells and promoting intercellular communication. MiRNA is a non-coding RNA consisting of 20-24 nucleotides that binds to the 3'UTR region of the target gene with a complementary nucleotide sequence during gene expression to degrade target mRNA or inhibit translation into target protein. In our study, exosomal miRNA profiling was utilized as a crucial technique to analyze the mechanisms of intercellular communication in tumor malignancy
Overall design We isolated exosomes from the conditioned medium of U251 cells overexpressing vector and Bcl-w. RNA was extracted from isolated exosomes and performed on a miRNA microarray.
Contributor(s) Bae IH, Choi JY, Seok HJ, Lee DH
Citation(s) 38521953
Submission date Mar 05, 2024
Last update date Mar 28, 2024
Contact name IN HWA BAE
Organization name Korea Institute of Radiological & Medical Sciences
Street address 75 Nowon-ro, Nowon-gu
City Seoul
State/province --- Select One ---
ZIP/Postal code 01812
Country South Korea
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (2)
GSM8127885 exomiRNA1
GSM8127886 exomiRNA2
BioProject PRJNA1083993

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE260909_RAW.tar 1.3 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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