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| Status |
Public on Jul 19, 2024 |
| Title |
Transcription profiling by array of mouse hepatocytes following treatment with growth factor beta 1 in a time series |
| Platform organism |
Homo sapiens |
| Sample organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To obtain a comprehensive view on the TGF-beta effects in primary mouse hepatocytes, Affymetrix microarrays were performed. We aimed at detecting early (1h), intermediate (6h) and late (24h and 48h) target genes.
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| Overall design |
Primary hepatocytes were used as an in vitro model to detect TGF-beta effects on the expression profile. In primary cell cultures, the majority of hepatocytes survive despite activated TGF-beta signaling. These cells display phenotypic characteristics for (partial) EMT and fibrogenesis.
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| Contributor(s) |
Hammad S, Delatorre C |
| Citation |
https://doi.org/10.1016/j.bbrc.2024.150409
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| Submission date |
Mar 08, 2024 |
| Last update date |
Jul 20, 2024 |
| Contact name |
Carolina Delatorre |
| E-mail(s) |
carolina.delatorre@medma.uni-heidelberg.de
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| Organization name |
University Heidelberg
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| Street address |
Theodor-Kutzer-Ufer 1-3
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| City |
Mannheim |
| ZIP/Postal code |
68167 |
| Country |
Germany |
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| Platforms (1) |
| GPL34289 |
[Clariom430_2] Affymetrix Mouse Genome 430 2.0 Arraz [CDF: Brainarray Mouse4302_Mm_ENTREZG_25.0.0] |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA1085777 |
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