|
| Status |
Public on Jun 20, 2024 |
| Title |
qPCR panels for plasma microRNAs of responders versus non responders metastatic castration resistant prostate cancer patients to abiraterone acetate |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by RT-PCR
|
| Summary |
Abiraterone acetate (AA) serves as a medication for managing persistent testosterone production in patients with metastatic castration-resistant prostate cancer (mCRPC). However, its efficacy varies among individuals, thus the identification of biomarkers to predict and follow treatment response is required. In this pilot study, we explored the potential of circulating miRNAs (c-miRNAs) to stratify patients based on their responsiveness to AA. We conducted a miRNA candidate analysis on 9 responders versus 9 non-responders mCRPC patients via Exiqon qPCR panels
The patients were considered responders to AA if they either achieved a radiological response without PSA progression and performance status deterioration, or in the presence of PSA reduction ≥ 50% compared to the baseline values without radiological progression and performance status deterioration.
|
| |
|
| Overall design |
miRNA candidate analysis on 9 responders versus 9 non-responders mCRPC patients via Exiqon qPCR panels
|
| |
|
| Contributor(s) |
Detassis S, Grasso M, Del Vescovo V, Denti MA |
| Citation(s) |
38891761 |
| |
| Submission date |
Mar 26, 2024 |
| Last update date |
Jun 20, 2024 |
| Contact name |
Simone Detassis |
| E-mail(s) |
simone.detassis@unitn.it
|
| Organization name |
University of Trento
|
| Department |
CIBIO
|
| Street address |
Via Sommarive 9
|
| City |
Trento |
| ZIP/Postal code |
38123 |
| Country |
Italy |
| |
|
| Platforms (1) |
| GPL34334 |
Exiqon microRNA Ready-to-Use PCR (miRCURY LNA Universal RT microRNA PCR Human panel I+II, V4.M – Qiagen) |
|
| Samples (18)
|
|
| Relations |
| BioProject |
PRJNA1092262 |
Less...
More...