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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 11, 2024 |
| Title |
Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We applied RNA sequencing to study the hepatic gene expression profile of Lep(ob/ob) mice fed the Amylin liver NASH (AMLN) diet for 14 weeks and then treated for 2 weeks with vehicle (n=10), obeticholic acid (OCA) (n=9), or INT-787 (n=9). INT-787, which is equipotent to OCA but more hydrophilic, modulated a substantially greater number of genes associated with FXR signaling, lipid metabolism, and stellate cell activation relative to OCA.
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| Overall design |
RNA-seq of poly A-enriched RNA isolated from ob/ob NASH mice treated with vehicle (n=10), obeticholic acid (n=9), or INT-787 (n=9).
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| Contributor(s) |
Rigbolt K, Adorini L, Feigh M, Roth J, Erickson M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Apr 04, 2024 |
| Last update date |
Apr 11, 2024 |
| Contact name |
Henrik Hansen |
| Organization name |
Gubra
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| Department |
Histology & NGS
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| Street address |
Hørsholm Kongevej 11
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| City |
Hørsholm |
| ZIP/Postal code |
2970 |
| Country |
Denmark |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (28)
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| GSM8188954 |
Liver, Vehicle, Rep 2 |
| GSM8188955 |
Liver, OCA 30 mg/kg, Rep 2 |
| GSM8188956 |
Liver, INT-787 30 mg/kg, Rep 2 |
| GSM8188957 |
Liver, Vehicle, Rep 3 |
| GSM8188958 |
Liver, OCA 30 mg/kg, Rep 3 |
| GSM8188959 |
Liver, INT-787 30 mg/kg, Rep 3 |
| GSM8188960 |
Liver, Vehicle, Rep 4 |
| GSM8188961 |
Liver, Vehicle, Rep 5 |
| GSM8188962 |
Liver, OCA 30 mg/kg, Rep 4 |
| GSM8188963 |
Liver, INT-787 30 mg/kg, Rep 4 |
| GSM8188964 |
Liver, Vehicle, Rep 6 |
| GSM8188965 |
Liver, INT-787 30 mg/kg, Rep 5 |
| GSM8188966 |
Liver, Vehicle, Rep 7 |
| GSM8188967 |
Liver, OCA 30 mg/kg, Rep 5 |
| GSM8188968 |
Liver, INT-787 30 mg/kg, Rep 6 |
| GSM8188969 |
Liver, Vehicle, Rep 8 |
| GSM8188970 |
Liver, OCA 30 mg/kg, Rep 6 |
| GSM8188971 |
Liver, INT-787 30 mg/kg, Rep 7 |
| GSM8188972 |
Liver, Vehicle, Rep 9 |
| GSM8188973 |
Liver, OCA 30 mg/kg, Rep 7 |
| GSM8188974 |
Liver, INT-787 30 mg/kg, Rep 8 |
| GSM8188975 |
Liver, Vehicle, Rep 10 |
| GSM8188976 |
Liver, OCA 30 mg/kg, Rep 8 |
| GSM8188977 |
Liver, INT-787 30 mg/kg, Rep 9 |
| GSM8188978 |
Liver, OCA 30 mg/kg, Rep 9 |
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| Relations |
| BioProject |
PRJNA1096425 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE263273_ob-ob_NASH_counts.txt.gz |
726.8 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
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