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| Status |
Public on Apr 16, 2024 |
| Title |
Single cell RNA-seq of aortas from Tet2flox/flox and Tet2SMC-KO mice receiving high-dosed cholecalciferol |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the role of TET2 in osteogenic differentiation of smooth muscle cells (SMCs) in vivo, we performed single cell RNA-seq in cholecalciferol overload-induced calcified aortas of Tet2flox/flox and SMC specific Tet2 knock-out mice (Tet2SMC-KO).
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| Overall design |
We performed single cell RNA sequencing (scRNAseq) of aorta tissues from the Tet2flox/flox mice receiving vehicle (WT) or high-dosed cholecalciferol (WT_VD) and Tet2SMC-KO mice receiving high-dosed cholecalciferol (KO_VD) , 3 replicates of each group.
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| Contributor(s) |
Zeng Z, Fan X, Tang W |
| Citation missing |
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| Submission date |
Apr 11, 2024 |
| Last update date |
Apr 16, 2024 |
| Contact name |
Xuejiao Fan |
| Organization name |
Guangzhou Women and Children’s Medical Centre
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| Department |
Institute of Pediatrics
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| Street address |
Tianhe District, Jinsui Road
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| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510623 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA1099142 |
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