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Series GSE263949 Query DataSets for GSE263949
Status Public on Apr 20, 2024
Title mRNA profile of PANC-1 treated with CAF-derived Evs
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Perineural invasion (PNI) is a unique biological feature of pancreatic cancer and is a key cause of pancreatic cancer metastasis, recurrence and poor postoperative survival, but its mechanism is largely unclarified. Clinical sample analysis and endoscopic ultrasonographic elasticity scoring indicated that cancer-associated fibroblasts (CAFs) are closely related to the occurrence of PNI. Furthermore, CAF-derived extracellular vesicles played an extremely important role in PNI in a dorsal root ganglion (DRG) coculture model and sciatic nerve model. Next, we demonstrated that CAFs promoted PNI via extracellular vesicle transmission of PNI-associated transcript (PIAT). To determine how CAF EVs exert its function, we performed mRNA sequencing on PANC-1 treated with CAFs-derived EVs
Overall design PANC-1 cells were pretreated with CAFs-derived Evs and collected for mRNA-seq.
Contributor(s) Zheng S, Hu C, Zhou Y, Chen R
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Submission date Apr 15, 2024
Last update date Apr 20, 2024
Contact name Chonghui Hu
Organization name Guangdong Provincial People’s Hospital
Street address NA Zhongshan 2nd Road, Guangzhou
City Guangzhou
ZIP/Postal code 5100080
Country China
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (6)
GSM8207852 PANC-1 cells, Control-rep1
GSM8207853 PANC-1 cells, Control-rep2
GSM8207854 PANC-1 cells, Control-rep3
BioProject PRJNA1100447

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Supplementary file Size Download File type/resource
GSE263949_M_vs_LN.DE_results.txt.gz 751.3 Kb (ftp)(http) TXT
GSE263949_mRNA-seq_All_gene_expression_count.txt.gz 443.5 Kb (ftp)(http) TXT
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