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Series GSE26457 Query DataSets for GSE26457
Status Public on Oct 25, 2012
Title Defining the Genomic Signature of the Parous Breast
Organism Homo sapiens
Experiment type Expression profiling by array
Summary It is widely accepted that a woman’s lifetime risk of developing breast cancer at menopause is reduced by early full term pregnancy and multiparity. This phenomenon is associated with the development and differentiation of the breast, which ultimately imprints a specific genomic profile in the mammary epithelium. In the present work we demonstrate that this profile represents a permanent signature that could be associated with the breast cancer risk reduction conferred by pregnancy.
We have compared the gene expression profile of normal breast biopsies performed in 71 parous (P) and 42 nulliparous (NP) postmenopausal women. All samples were hybridized to Affymetrix HG_U133 Plus 2.0 oligonucleotide arrays.
 
Overall design We compared the gene expression profile of normal breast core biopsies from 71 parous (women that had a full term pregnancy) and 42 nulliparous (women that never completed a pregnancy) postmenopausal women from Sweden. All samples were hybridized to Affymetrix HG_U133 Plus 2.0 oligonucleotide arrays.
 
Contributor(s) Peri S, López de Cicco R, Santucci-Pereira J, Slifker M, Ross E, Russo IH, Russo PA, Arslan AA, Belitskaya-Lévy I, Zeleniuch-Jacquotte A, Bordas P, Lenner P, Åhman J, Afanasyeva Y, Johansson R, Sheriff F, Hallmans G, Toniolo P, Russo J
Citation(s) 23057841, 22025034
Submission date Jan 05, 2011
Last update date Mar 25, 2019
Contact name Julia Santucci-Pereira
E-mail(s) ju.delbuono@gmail.com
Organization name Fox Chase Cancer Center
Lab The Irma H. Russo, MD Breast Cancer Research Laboratory
Street address 333 Cottman Ave, P2051
City Philadelphia
State/province PA
ZIP/Postal code 19111
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (113)
GSM649360 nulliparous-rep1-batch D.1
GSM649361 nulliparous-rep2-batch D.7
GSM649362 nulliparous-rep3-batch D.4
Relations
BioProject PRJNA136563

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26457_RAW.tar 609.8 Mb (http)(custom) TAR (of CEL)
GSE26457_RMA_MAS5calls.xls.gz 69.3 Mb (ftp)(http) XLS
Processed data included within Sample table
Processed data are available on Series record

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