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Series GSE265794 Query DataSets for GSE265794
Status Public on May 18, 2024
Title TGFBR3 inhibits the aggressive of papillary thyroid cancer by inhibiting PI3K/AKT pathway and EMT
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Transforming Growth Factor Beta Receptor III (TGFBR3) had been shown to play a tumor suppressor role in a variety of cancers. However, its role in papillary thyroid cancer (PTC) remains a mystery. The purpose of this study was to determine the molecular mechanism and biological behavior of TGFBR3 in PTC, to further explore the regulatory pathway involved in TGFBR3 on PTC and provide potential targets for the diagnosis and treatment of invasive PTC.
Overall design To explore the expression of TGFBR3 in PTC. Construct TGFBR3 overexpression cell line, explore the influence of TGFBR3 overexpression on PTC cells. Explore the downstream pathway of TGFBR3 on PTC. Investigate how TGFBR3 regulates the biological behavior of PTC through PI3K/AKT and EMT.
Contributor(s) Zhang H, Chen J, Chen X, Li H
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Submission date Apr 24, 2024
Last update date May 18, 2024
Contact name zhang han rong
Phone 15767745273
Organization name The First Affiliated Hospital of SunYat-sen University
Street address Zhong shan Second Road
City Guang Zhou
State/province Guang dong Province
ZIP/Postal code 510000
Country China
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (6)
GSM8229348 KTC1 cells,Empty_vector-1,rep1
GSM8229349 KTC1 cells,Empty_vector-2,rep2
GSM8229350 KTC1 cells,Empty_vector-3,rep3
BioProject PRJNA1104217

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Supplementary file Size Download File type/resource
GSE265794_All.fpkm.exp_anno.xlsx 7.7 Mb (ftp)(http) XLSX
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Raw data are available in SRA

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