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| Status |
Public on May 10, 2024 |
| Title |
Retinal inflammation mediated by mineralocorticoid receptor activation depends on its ligands |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Transgenic rats overexpressing human mineralocorticoid receptor (hMR) under the control of the ecologic promotor 1 (P1.hMR rats) were used as well as their WT littermates. We observed low grade inflammation, RPE abnormatilites and anatomical signs of choroidal neuropathy in these rats. Bulk-transcriptomic analysis of neuroretinas was peformed to identify potential mechanisms.
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| Overall design |
Animals were sacrified and eyes were freshly dissected to extract RNA from neuroretinas for transcriptomic analysis.
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| Contributor(s) |
Leclercq B, Behar-Cohen F, Zhao M |
| Citation missing |
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| Submission date |
May 01, 2024 |
| Last update date |
May 10, 2024 |
| Contact name |
Bastien Leclercq |
| E-mail(s) |
baslecq@gmail.com
|
| Organization name |
INSERM
|
| Lab |
Centre de Recherche des Cordeliers
|
| Street address |
15 Rue de l'École de Médecine
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| City |
Paris |
| State/province |
Ile-de-France |
| ZIP/Postal code |
75006 |
| Country |
France |
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| Platforms (1) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA1106852 |
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