GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE267014 Query DataSets for GSE267014
Status Public on May 13, 2024
Title Spermine-induced DNA methylation change in human macrophages
Platform organisms Leptospira interrogans; Campylobacter jejuni; Francisella tularensis subsp. novicida; Yersinia enterocolitica; Yersinia pestis; Yersinia pseudotuberculosis; Rickettsia prowazekii; Rickettsia typhi; Bartonella quintana; Staphylococcus aureus; Mycobacterium avium; Mycobacterium tuberculosis variant bovis; Mycobacterium avium subsp. paratuberculosis; Mycobacterium tuberculosis; Mycobacterium tuberculosis variant microti; Toxoplasma gondii; Cowpox virus; Streptobacillus moniliformis; Bartonella henselae; Mycobacterium canetti; Escherichia coli O157:H7; Salmonella enterica subsp. enterica serovar Typhimurium; Francisella tularensis subsp. tularensis; Francisella tularensis subsp. holarctica; Francisella tularensis subsp. mediasiatica; Paslahepevirus balayani; Mammarenavirus choriomeningitidis; Orthohantavirus puumalaense; Orthohantavirus seoulense
Sample organism Homo sapiens
Experiment type Methylation profiling by array
Summary Polyamines, crucial molecules involved in cell proliferation and growth, play a pivotal role in cancer development and progression. Within the tumor microenvironment, macrophages, key components of the immune system, exhibit a complex relationship with polyamines. Evidence suggests that polyamines can modulate macrophage polarization, influencing their functional phenotypes. Here, we detected the gene DNA methylation changes in spermine-stimulated human macrophages isolated from PBMCs and TAMs.
Overall design Bisulphite converted DNA from the 4 samples were hybridised to human 850K llumina Infinium MethylationEPIC BeadChip .
Contributor(s) Zhu Y, Hu H
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date May 08, 2024
Last update date May 13, 2024
Contact name Hongde Li
Organization name Hangzhou Institute of Medicine, Chinese Academy of Sciences
Street address 150 Fucheng Road
City Hangzhou
State/province Zhejiang
ZIP/Postal code 310022
Country China
Platforms (1)
GPL21445 WT_Rodent_Chip_03
Samples (4)
GSM8258455 genomic DNA from M0 macrophage with PBS
GSM8258456 genomic DNA from M0 macrophage with spermine
GSM8258457 genomic DNA from normal M0 macrophage
BioProject PRJNA1109345

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE267014_Matrix_processed_data.txt.gz 15.5 Mb (ftp)(http) TXT
GSE267014_RAW.tar 55.5 Mb (http)(custom) TAR (of IDAT)

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap