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| Status |
Public on May 13, 2024 |
| Title |
Spermine-induced DNA methylation change in human macrophages |
| Platform organisms |
Leptospira interrogans; Campylobacter jejuni; Francisella tularensis subsp. novicida; Yersinia enterocolitica; Yersinia pestis; Yersinia pseudotuberculosis; Rickettsia prowazekii; Rickettsia typhi; Bartonella quintana; Staphylococcus aureus; Mycobacterium avium; Mycobacterium tuberculosis variant bovis; Mycobacterium avium subsp. paratuberculosis; Mycobacterium tuberculosis; Mycobacterium tuberculosis variant microti; Toxoplasma gondii; Cowpox virus; Streptobacillus moniliformis; Bartonella henselae; Mycobacterium canetti; Escherichia coli O157:H7; Salmonella enterica subsp. enterica serovar Typhimurium; Francisella tularensis subsp. tularensis; Francisella tularensis subsp. holarctica; Francisella tularensis subsp. mediasiatica; Paslahepevirus balayani; Mammarenavirus choriomeningitidis; Orthohantavirus puumalaense; Orthohantavirus seoulense |
| Sample organism |
Homo sapiens |
| Experiment type |
Methylation profiling by array
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| Summary |
Polyamines, crucial molecules involved in cell proliferation and growth, play a pivotal role in cancer development and progression. Within the tumor microenvironment, macrophages, key components of the immune system, exhibit a complex relationship with polyamines. Evidence suggests that polyamines can modulate macrophage polarization, influencing their functional phenotypes. Here, we detected the gene DNA methylation changes in spermine-stimulated human macrophages isolated from PBMCs and TAMs.
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| Overall design |
Bisulphite converted DNA from the 4 samples were hybridised to human 850K llumina Infinium MethylationEPIC BeadChip .
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| Contributor(s) |
Zhu Y, Hu H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
May 08, 2024 |
| Last update date |
May 13, 2024 |
| Contact name |
Hongde Li |
| E-mail(s) |
hongde.li@hotmail.com
|
| Organization name |
Hangzhou Institute of Medicine, Chinese Academy of Sciences
|
| Street address |
150 Fucheng Road
|
| City |
Hangzhou |
| State/province |
Zhejiang |
| ZIP/Postal code |
310022 |
| Country |
China |
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| Platforms (1) |
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| Samples (4)
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| GSM8258455 |
genomic DNA from M0 macrophage with PBS |
| GSM8258456 |
genomic DNA from M0 macrophage with spermine |
| GSM8258457 |
genomic DNA from normal M0 macrophage |
| GSM8258458 |
genomic DNA from TAMs induced by MDA-MB-231 cell-conditioned medium |
|
| Relations |
| BioProject |
PRJNA1109345 |
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