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Series GSE267794 Query DataSets for GSE267794
Status Public on Jun 17, 2024
Title Transcriptome landscape of the adrenal gland and superior cervical ganglion from hypertension-induced left ventricular hypertrophy rat model
Organism Rattus norvegicus
Experiment type Expression profiling by high throughput sequencing
Summary Hypertension-induced left ventricular hypertrophy (LVH) is a cardiac structural remodeling and dysfunction resulting from chronic hypertension and is an independent risk factor for cardiovascular morbidity and mortality. Studies have implicated the involvement of the adrenal gland (AG) and superior cervical ganglion (SCG) in hypertension regulation. However, the molecular mechanisms of AG and SCG during hypertension-induced LVH remain unclear. In this study, we investigated the transcriptome characteristics of the left ventricle, AG, and SCG in 24-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats using transcriptome sequencing (RNA-seq) technology. We identified 671 differentially expressed genes (DEGs) in the left ventricle, 1596 DEGs in the AG, and 343 DEGs in the SCG between SHR and WKY rats. Functional analysis revealed that these DEGs were involved in pathways related to immune inflammation, metabolic responses, and synaptic transmission. Further analysis demonstrated the presence of crosstalk among DEGs across these three organs, including 63 overlapping DEGs among these three organs, of which 59 DEGs exhibited consistent changes. In summary, we elucidates the transcriptome features of AG and SCG during hypertension-induced LVH in SHR, highlighting the complex molecular interactions across multiple organs.
 
Overall design Comparative gene expression profiling analysis of RNA-seq data for the left ventricle, AG, and SCG in 24-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats.
 
Contributor(s) Li C, Liu F, Li X, Yang X, Li Q, Huang J
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BioProject PRJNA1102340
Submission date May 17, 2024
Last update date Jun 17, 2024
Contact name Chaohong Li
E-mail(s) lichaohong@stu.cqmu.edu.cn, sxycjslch@163.com
Organization name Chongqing Medical University
Street address Yuzhong Road
City Chongqing
ZIP/Postal code 400000
Country China
 
Platforms (1)
GPL30103 DNBSEQ-G400 (Rattus norvegicus)
Samples (24)
GSM8278871 Left ventricle, WKY, rep1
GSM8278872 Left ventricle, WKY, rep2
GSM8278873 Left ventricle, WKY, rep3

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Supplementary file Size Download File type/resource
GSE267794_FPKMs_allsamples.xls.xlsx 5.1 Mb (ftp)(http) XLSX
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Raw data are available in SRA

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