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Series GSE26793 Query DataSets for GSE26793
Status Public on Jan 21, 2011
Title Genome-wide binding of Ubx and Hth in 3rd thoracic imaginal discs
Project modENCODE
Organism Drosophila melanogaster
Experiment type Genome binding/occupancy profiling by genome tiling array
Summary The Hox genes are responsible for generating morphological diversity along the anterior-posterior axis during animal development. The Drosophila Hox gene Ultrabithorax (Ubx), for example, is required for specifying the identity of the third thoracic (T3) segment of the adult, which includes the dorsal haltere, an appendage required for flight, and the ventral T3 leg. Ubx mutants show homeotic transformations of the T3 leg towards the identity of the T2 leg and the haltere towards the wing. All Hox genes, including Ubx, encode homeodomain containing transcription factors, raising the question of what target genes Ubx regulates to generate these adult structures. To address this question, we carried out whole genome ChIP-chip studies to identify all of the Ubx bound regions in the haltere and T3 leg imaginal discs, which are the precursors to these adult structures. In addition, we used ChIP-chip to identify the sites bound by the Hox cofactor, Homothorax (Hth).
This is a dataset generated by the Drosophila Regulatory Elements modENCODE Project led by Kevin P. White at the University of Chicago. This dataset was generated in collaboration with Richard S. Mann at Columbia University. It contains ChIP-chip data on Affymetrix Drosophila Tiling 2.0R arrays for multiple transcription factor antibodies in multiple Drosophila tissues.

For data usage terms and conditions, please refer to and
Overall design Haltere or leg imaginal discs ChIPped for Ubx or Hth vs. input DNA from corresponding imaginal discs. For each combination of tissue and antibody, ChIP experiments have been performed and hybridized on Affymetrix Drosophila Tiling 2.0R arrays. At least 3 biological replicates for the ChIP sample have been hybridized.
Web link
Contributor(s) Slattery M, Negre N, Bild N, Mann RS, White KP
Citation(s) 21483663
BioProject PRJNA63463
Submission date Jan 21, 2011
Last update date Jul 08, 2015
Contact name Matthew Slattery
Organization name University of Minnesota Medical School
Street address 1035 University Drive, SMed 219
City Duluth
State/province MINNESOTA
ZIP/Postal code 55812
Country USA
Platforms (1)
GPL6629 [DM_tiling2_MR] Affymetrix Drosophila Tiling 2.0R Array
Samples (4)
GSM659162 UBX_Haltere
GSM659163 UBX_Leg
GSM659164 HTH_Haltere
This SubSeries is part of SuperSeries:
GSE23537 modENCODE_White Lab: genome-wide ChIP-chip and ChIP-Seq data

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26793_RAW.tar 927.9 Mb (http)(custom) TAR (of BAR, BED, CEL)
Processed data provided as supplementary file

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