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Series GSE268746 Query DataSets for GSE268746
Status Public on Aug 20, 2024
Title N6-methyladenosine (m6A) modification in HaCaT cells (immortalized human keratinocyte cell line) treated with STM2457 in the presence or absence of M5 (inflammatory factor cocktail) stimulation [MeRIPseq_KC]
Organism Homo sapiens
Experiment type Methylation profiling by high throughput sequencing
Other
Summary We conducted an analysis of N6-methyladenosine (m6A) modifications in HaCaT cells, an immortalized human keratinocyte cell line, following treatment with METTL3 inhibitor, STM2457, under conditions of either M5 (inflammatory factor cocktail) stimulation or its absence. The primary aim of this investigation was to establish a molecular framework elucidating the role of m6A modifications in modulating the functional dynamics of keratinocytes within an inflammatory milieu.
 
Overall design HaCaT cells were subjected to a 24-hour treatment regimen with the METTL3 inhibitor STM2457, succeeded by a subsequent 24-hour exposure to either M5 or phosphate-buffered saline (PBS). Each experimental group comprised two replicates.
 
Contributor(s) Cui L, Wu Y, Li B, Gao Y
Citation(s) 39356764
Submission date May 31, 2024
Last update date Oct 15, 2024
Contact name Lian Cui
E-mail(s) liancui2023@126.com
Phone +8618221212636
Organization name Shanghai Skin Disease Hospital
Street address 1278 Baode Road
City Shanghai
State/province China
ZIP/Postal code 200072
Country China
 
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (16)
GSM8298340 pbs-dmso-1-input
GSM8298341 pbs-dmso-1-ip
GSM8298342 pbs-dmso-2-input
Relations
BioProject PRJNA1118668

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Supplementary file Size Download File type/resource
GSE268746_RAW.tar 444.3 Mb (http)(custom) TAR (of BW)
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Raw data are available in SRA

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