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| Status |
Public on Oct 16, 2024 |
| Title |
Gene expression profiles of PD-L1 positive and PD-L1 negative lung neutrophils from Influenza A virus infected mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Neutrophils are often considered as foes during severe lung infections through their ability to secrete inflammatory mediators and participate in lung damages. Here, we used single cell RNA-sequencing (scRNA-seq) to assess the transcriptional heterogeneity of neutrophils in mice with severe lung infection caused by influenza A virus
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| Overall design |
Lung neutrophils from IAV (H3N2/Scotland/74 strain) infected C57BL/6j femelle mice (day 11 post-infection) were isolated using a cell sorter based on PD-L1 expression.
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| Contributor(s) |
Gonzalez L, Lemoine R, Ilango G, Paget C |
| Citation(s) |
39392875 |
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| Submission date |
Jun 04, 2024 |
| Last update date |
Oct 17, 2024 |
| Contact name |
Guy Ilango |
| E-mail(s) |
guy.ilango@univ-tours.fr
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| Organization name |
University of Tours
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| Lab |
Centre d'Etude des Pathologies Respiratoires
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| Street address |
10, boulevard Tonnellé
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| City |
Tours |
| ZIP/Postal code |
37000 |
| Country |
France |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA1120061 |
